Punch-Out!! is a boxing video game series created by Genyo Takeda, and published by Nintendo. The player controls Little Mac, a boxer who aims to become the World Video Boxing Association (W.V.B.A.) champion.

The original Punch-Out!! arcade game was first released in 1984, and was quickly followed by a sequel, titled Super Punch-Out!!. The series received its first home console entry in 1987, with Mike Tyson's Punch-Out!! for the Nintendo Entertainment System. In 1994, Super Punch-Out!! was released for the Super Nintendo Entertainment System. While not a direct port, it features gameplay more similar to the arcade games, rather than its NES predecessor.

Following a period of dormancy, the series was rebooted with Punch-Out!!, first released in 2009 for the Wii, along with a Club Nintendo-exclusive prequel, Doc Louis's Punch-Out!!. The series has received critical and commercial acclaim, with the NES game selling three million copies alone.

Spin-offs were also released, namely Punch-Out!! / Boxing (Game & Watch) in 1984, and Arm Wrestling in 1985.

Playing as Little Mac, a 17-year old boxer from The Bronx, the player must climb the ranks of the World Video Boxing Association (W.V.B.A.), and fight their way against other boxers from around the world, going from the Minor Circuit then the Major Circuit and then the World Circuit, while fighting challengers including Glass Joe, King Hippo, Piston Hondo, Don Flamenco, Bald Bull, Mr. Sandman, or in the original NES version, the former heavyweight boxing champion himself, Mike Tyson. Gameplay differs slightly between each game, but generally, Mac can attack using his left and right fists, performing either a hook, a dodge, or a jab. He can also dodge and block to avoid the opponent's attacks, the block dealing less damage. Many games in the series give the player a powerful uppercut ability; its use is limited, must be earned during matches, and is earned from well-timed punches or rapid combos, depending on the game.

The key to defeating each opponent is to learn their fighting patterns, avoid their attacks and respond with a counterattack. Opponents will always give a visual or audible cue to signal their next attack, though as the game progresses, the time given to the player to successfully react significantly decreases. If the player successfully dodges an attack, the opponent will be left vulnerable for a while, allowing the player to strike back. Little Mac can block some of his opponent's punches by holding up his gloves, but he will eventually tire out if he blocks or gets hit too much.

Punch-Out!! was first released on February 17, 1984 in Japan. The concept originated as Nintendo had acquired an excessive number of video monitors following the success of Donkey Kong (1981). Tasked with creating a game that used two monitors per cabinet, Genyo Takeda of Nintendo R&D3 suggested they make a boxing game.

The game was re-released by Hamster as part of their Arcade Archives series in 2018 for Nintendo Switch.