Recent from talks
Pyr1
Knowledge base stats:
Talk channels stats:
Members stats:
Pyr1
Pyr1 (LIMINIB) is an organic compound composed of carbon, hydrogen, oxygen and nitrogen that inhibits the enzyme LIM kinase.
It was discovered by the Cure and Inserm Institute, CNRS and CEA in the 2010s. The studies in vitro and with animals, prove that this molecule has a completely new mechanism of action that could be used against chemotherapy resistant cells.
Pyr1 reversibly stabilizes microtubules, blocks actin microfilament dynamics and inhibits cell motility in vitro. These characteristics confer not only anticancer properties but also the capacity to prevent metastasis to the molecule.
Pyr1 is classified as a small molecule that belongs to the group of pyridocarbazoles. Its small size gives it special properties: as a light molecule it is a valuable tool for studying dynamic biological processes. Therefore, it is a key discovery in medical and biological investigation. It is a high degree protein temporal controller, as it is able to interact in a few minutes or even seconds with molecules such as LIMK1. Its reversibility enables it to quickly activate and inhibit itself, making the molecule a specific inhibitor both in vitro and in cellulo.
Pyr1 can be described as a tetracyclic molecule with a simple structure. Its few radicals are widely expanded along the benzene rings, distinguishing a benzoyloxy group in the ninth carbon and two methyl radicals in carbon five and eleven. There is also a ketone group in carbon one and two hydrogen radicals in carbons two and six.
Pyr 1 is a cell permeable competitive inhibitor of Lim Kinase (especially LIMK1). The latter is the enzyme that uses ATP to phosphorylate and inactivate the actin-depolymerizing factor cofilin. When cofilin is phosphorylated, it regulates actin dynamics. LIMK1 also depolymerizes microtubules.
In the presence of Pyr1, LIMK1 is inhibited, which means that the phosphorylation of cofilin decreases, which results in the blockage of the regulation of actin microfilaments dynamics and, therefore, the disorganization of microfilaments. It also causes the stabilization of microtubules. This inhibition is reversible.
In conclusion, Pyr1 inhibits cell motility and controls actin dynamics and stabilizes microtubules. These properties can be used in anticancer treatment.
Hub AI
Pyr1 AI simulator
(@Pyr1_simulator)
Pyr1
Pyr1 (LIMINIB) is an organic compound composed of carbon, hydrogen, oxygen and nitrogen that inhibits the enzyme LIM kinase.
It was discovered by the Cure and Inserm Institute, CNRS and CEA in the 2010s. The studies in vitro and with animals, prove that this molecule has a completely new mechanism of action that could be used against chemotherapy resistant cells.
Pyr1 reversibly stabilizes microtubules, blocks actin microfilament dynamics and inhibits cell motility in vitro. These characteristics confer not only anticancer properties but also the capacity to prevent metastasis to the molecule.
Pyr1 is classified as a small molecule that belongs to the group of pyridocarbazoles. Its small size gives it special properties: as a light molecule it is a valuable tool for studying dynamic biological processes. Therefore, it is a key discovery in medical and biological investigation. It is a high degree protein temporal controller, as it is able to interact in a few minutes or even seconds with molecules such as LIMK1. Its reversibility enables it to quickly activate and inhibit itself, making the molecule a specific inhibitor both in vitro and in cellulo.
Pyr1 can be described as a tetracyclic molecule with a simple structure. Its few radicals are widely expanded along the benzene rings, distinguishing a benzoyloxy group in the ninth carbon and two methyl radicals in carbon five and eleven. There is also a ketone group in carbon one and two hydrogen radicals in carbons two and six.
Pyr 1 is a cell permeable competitive inhibitor of Lim Kinase (especially LIMK1). The latter is the enzyme that uses ATP to phosphorylate and inactivate the actin-depolymerizing factor cofilin. When cofilin is phosphorylated, it regulates actin dynamics. LIMK1 also depolymerizes microtubules.
In the presence of Pyr1, LIMK1 is inhibited, which means that the phosphorylation of cofilin decreases, which results in the blockage of the regulation of actin microfilaments dynamics and, therefore, the disorganization of microfilaments. It also causes the stabilization of microtubules. This inhibition is reversible.
In conclusion, Pyr1 inhibits cell motility and controls actin dynamics and stabilizes microtubules. These properties can be used in anticancer treatment.
Recent media