The Quartermaster Center and School is a formation of the United States Army's Combined Arms Support Command, and is located at Fort Lee, Virginia. The school is operated by the 23rd Quartermaster Brigade and its assigned units.^{[citation needed]}

The school was initiated on 1 March 1910, at the Philadelphia Depot, under Brig. Gen. James B. Aleshire as a school for Quartermaster sergeants at recruit depots. The school was founded ad a response to criticisms that military uniforms were issued that were poorly fitted and sloppy in appearance. The goal of the school was that the sergeants would become the "storekeepers of the Army."

In 1912, the army combined the commissary and pay departments with the Quartermaster Corps resulting in an increase in duties for quartermaster sergeants and the school was no officially called The Quartermaster Corps School.

With the start of World War I, the school began its first ever class for officers.

The school moved to Schuylkill Arsenal in Pennsylvania in 1921 (but some classes continued in Philadelphia until 1925) and a warrant officers class was instituted that same year.

In 1934, the army approved Colonel Francis H. Pope's idea for a Quartermaster Corps Board to look for improvements and make recommendations for the quartermaster corps.

In 1940, with war likely, the War Department ordered the quartermaster school to create a 3-month officers course to replace the current 9-month course in order to speed the training of new officers. What followed were shortened enlisted courses, ROTC cadet classes and officer candidate school (OCS).

During World War II, despite expanding into vacant buildings in the nearby community, the facilities at Schuylkill Arsenal grew overcrowded. On 6 October 1941, the school officially moved to Camp Lee (now Fort Lee) in Virginia. The school was set up on over 500 acres of land from the Department of the Interior that was previously Petersburg National Military Park.