A quasi-experiment is a research design used to estimate the causal impact of an intervention. Quasi-experiments share similarities with experiments and randomized controlled trials, but specifically lack random assignment to treatment or control. Instead, quasi-experimental designs typically allow assignment to treatment condition to proceed how it would in the absence of an experiment.

Quasi-experiments are subject to concerns regarding internal validity, because the treatment and control groups may not be comparable at baseline. In other words, it may not be possible to convincingly demonstrate a causal link between the treatment condition and observed outcomes. This is particularly true if there are confounding variables that cannot be controlled or accounted for.

With random assignment, study participants have the same chance of being assigned to the intervention group or the comparison group. As a result, differences between groups on both observed and unobserved characteristics would be due to chance, rather than to a systematic factor related to treatment (e.g., illness severity). Randomization itself does not guarantee that groups will be equivalent at baseline. Any change in characteristics post-intervention is likely attributable to the intervention.

The first part of creating a quasi-experimental design is to identify the variables. The quasi-independent variable is the variable that is manipulated in order to affect a dependent variable. It is generally a grouping variable with different levels. Grouping means two or more groups, such as two groups receiving alternative treatments, or a treatment group and a no-treatment group (which may be given a placebo – placebos are more frequently used in medical or physiological experiments). The predicted outcome is the dependent variable. In a time series analysis, the dependent variable is observed over time for any changes that may take place. One or more covariates are usually included in analyses, ideally variables that predict both the treatment group and the outcome. These are additional variables that are often used to address confounding, e.g., through statistical adjustment or matching. Once the variables have been identified and defined, a procedure should then be implemented and group differences should be examined.

In an experiment with random assignment, study units have the same chance of being assigned to a given treatment condition. As such, random assignment ensures that both the experimental and control groups are equivalent. In a quasi-experimental design, assignment to a given treatment condition is based on something other than random assignment. Depending on the type of quasi-experimental design, the researcher might have control over assignment to the treatment condition but use some criteria other than random assignment (e.g., a cutoff score) to determine which participants receive the treatment, or the researcher may have no control over the treatment condition assignment and the criteria used for assignment may be unknown. Factors such as cost, feasibility, political concerns, or convenience may influence how or if participants are assigned to a given treatment conditions, and as such, quasi-experiments are subject to concerns regarding internal validity (i.e., can the results of the experiment be used to make a causal inference?).

Quasi-experiments are also effective because they use the "pre-post testing". This means that there are tests done before any data are collected to see if there are any person confounds or if any participants have certain tendencies. Then the actual experiment is done with post test results recorded. This data can be compared as part of the study or the pre-test data can be included in an explanation for the actual experimental data. Quasi experiments have independent variables that already exist such as age, gender, eye color. These variables can either be continuous (age) or they can be categorical (gender). In short, naturally occurring variables are measured within quasi experiments.

There are several types of quasi-experimental designs, each with different strengths, weaknesses and applications. These designs include (but are not limited to):

Of all of these designs, the regression discontinuity design comes the closest to the experimental design, as the experimenter maintains control of the treatment assignment and it is known to "yield an unbiased estimate of the treatment effects". It does, however, require large numbers of study participants and precise modeling of the functional form between the assignment and the outcome variable, in order to yield the same power as a traditional experimental design.