Repo! The Genetic Opera is a 2008 American musical film. Described as a gothic rock opera, the film was directed by Darren Lynn Bousman and based on the 2002 stage musical of the same name, written and composed by Darren Smith and Terrance Zdunich. It stars Alexa Vega, Anthony Stewart Head, Sarah Brightman, Paris Hilton, Nivek Ogre, Terrance Zdunich, Bill Moseley, and Paul Sorvino.

Repo! premiered at the Fantasia Film Festival in July 2008, followed by a limited release on November 7, 2008, on seven screens in various cities. It received mixed-negative reviews, with primary criticism for its bombastic gore and writing. However, the performances were praised. Similarly to, but not to the same extent as, The Rocky Horror Picture Show, Repo! has achieved cult status and a devoted following.

By the year 2056, an epidemic of organ failures has devastated the planet and wiped out 99% of the human population. The megacorporation GeneCo provides organ transplants on a payment plan. Clients who miss payments are hunted down by Repo Men, skilled assassins who "repossess" the organs ("Genetic Repo Man"). The CEO of GeneCo, Rotti Largo, discovers he is terminally ill. Rotti's children Luigi, Pavi, and Amber bicker over who will inherit GeneCo ("Mark It Up"), but Rotti believes none of them are worthy heirs and instead plans to give his fortune to 17-year-old Shilo Wallace, the daughter of his late ex-fiancée Marni ("Things You See in a Graveyard").

Shilo has inherited a rare blood disease from Marni that requires her to stay indoors, though she longs to see the outside world ("Infected"). Shilo's overprotective father, Nathan, believes he accidentally killed Marni with a treatment he created for her illness – in truth, a jealous Rotti secretly poisoned Marni's medicine and blackmailed Nathan, promising not to arrest him for manslaughter if he agreed to become GeneCo's head Repo Man, though he has convinced Shilo he is a doctor ("Legal Assassin"). One night, Shilo secretly visits Marni's tomb and runs into the omniscient GraveRobber, who is digging up bodies to extract Zydrate, a euphoric and addictive painkiller that he sells on the street to keep up with his GeneCo payments ("21st Century Cure").

Rotti lures Shilo to GeneCo's fair with promises of a cure for her disease. There, she meets Blind Mag, an opera singer and GeneCo's celebrity spokesperson. Born blind, Mag has been given surgically enhanced eyes by GeneCo at the cost of indefinite employment, though she is soon resigning. GraveRobber helps Shilo escape the fairgrounds, encountering several of his customers, including the surgery-addicted Amber ("Zydrate Anatomy"). Shilo learns that Mag's eyes are set for repossession because of her planned resignation and that Amber will replace her as GeneCo's spokeswoman. After GeneCops arrive, Shilo quickly returns to her room before Nathan notices her missing.

Nathan refuses to repossess Mag's eyes, citing her close friendship with Marni ("Night Surgeon"). Infuriated, Rotti vows to have Nathan taken out. Mag visits Shilo, reveals that she is her godmother and that Nathan had told her Shilo died alongside Marni, and cautions Shilo not to make the same mistakes she did ("Chase The Morning"). Nathan arrives and ousts Mag after she scolds him for lying to her and incarcerating Shilo ("Everyone's a Composer"). Shilo begs him to let Mag hide from the Repo Man in their house, but Nathan refuses, leading Shilo to snap and finally condemn her father for his overbearing treatment of her and inability to move on from Marni's death ("Seventeen"). Meanwhile, Rotti writes his will, ready to make Shilo his sole beneficiary ("Gold").

Rotti invites Shilo to the Opera, where he swears to cure her blood disease if she helps him nab the Repo Man, not revealing that it's her father. Nathan heads out to find her, pursued by GeneCops, whom he quickly dispatches ("At the Opera Tonight"). Amber makes her stage debut, but her performance is ruined when her transplanted face falls off. Mag completes her final performance, but deviates from the song's grand finale, denouncing the Largo family and gouging out her eyes in an act of defiance ("Chromaggia"). Rotti cuts the cords suspending Mag, impaling her on a fence, but assures the panicking audience that Mag's death was staged as part of the show.

Shilo is used as a trap for the Repo Man. When he approaches a fake Mag tied to a chair, Shilo attacks him with a shovel, revealing him as Nathan, much to her horror ("Let the Monster Rise"). Onstage, Rotti reveals that Nathan has been poisoning Shilo's "medicine" in an attempt to keep her safe from the outside world after being unable to cope with the loss of Marni. As his health rapidly declines, Rotti offers Shilo GeneCo if she kills her father. When she refuses, Rotti uses the last of his strength to fatally shoot Nathan, and dies after disowning his children. After a tearful farewell to her father ("I Didn't Know I'd Love You So Much"), Shilo decides that Nathan's actions do not dictate her future ("Genetic Emancipation").