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Rudolph Nissen

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Rudolph Nissen

Rudolph Nissen (sometimes spelled Rudolf Nissen) (September 5, 1896 – January 22, 1981) was a German surgeon who chaired surgery departments in Turkey, the United States and Switzerland. The Nissen fundoplication, a surgical procedure for the treatment of gastroesophageal reflux disease, is named after him.

Nissen trained under German physicians Ludwig Aschoff and Ferdinand Sauerbruch. He completed the first pneumonectomy in 1931. In 1948, he performed an abdominal surgery that extended the life of Albert Einstein by several years. Nissen wrote an autobiography published at Deutsche Verlags-Anstalt in 1969 called "Helle Blätter, dunkle Blätter. Erinnerungen eines Chirurgen". (ISBN 978-3421014993) which was reviewed in the Journal of the American College of Surgeons.[circular reference] A selection of his writings and lectures was published at Schattauer in 1997 under the title of "Fünfzig Jahre erlebter Chirurgie: Ausgewählte Vorträge und Schriften."(ISBN 978-3794506156).

Nissen was born in a Jewish-German family in Neisse, Silesia, German Empire, in 1896. He was the son of Franz Nissen, a well-known surgeon. Rudolph Nissen pursued medical studies in Munich, Marburg and Breslau. He then trained in pathology under influential physician Ludwig Aschoff at the University of Freiburg. During the First World War he served in a medical corps unit and was severely injured by a gunshot in his lung which led to lifelong problems. He finished his medical studies after the war. In 1921, he came to the University of Munich as an assistant to German surgeon Ferdinand Sauerbruch. Six years later, Sauerbruch and Nissen moved to the Charité at the University of Berlin. In 1933, Nissen became the surgery department head at Istanbul University. The move was prompted by Hitler's Jewish boycott, although Nissen was at first not directly affected by anti-Jewish legislation because he had been an active World War I front soldier.

Nissen left Turkey for the United States in 1939, and later moved to the United States. He was a surgery research fellow at Massachusetts General Hospital for two years, and spent several years in New York as chair of the surgery programs at Jewish Hospital and Maimonides Medical Center. He was a department head at the University of Basel from 1952 to his retirement in 1967. He died in 1981 in Riehen.

While in Istanbul in 1936, Nissen excised an esophageal ulcer from a 28-year-old patient. The operation required Nissen to remove a portion of the lower esophagus and join the remaining esophagus to the stomach. In an effort to avoid the backflow of stomach contents into the patient's esophagus, Nissen wrapped (plicated) folds of the patient's upper stomach around the lower esophagus. Following the patient subsequently, Nissen noted that the patient's problems with heartburn improved after surgery.

Through the 1940s and 1950s, Nissen treated many patients with hiatal hernias using conventional methods developed by other surgeons. He even performed one of these procedures, an anterior gastropexy, on eminent radiologist Gustav Bucky. Bucky was very ill when he presented to Nissen, but he completely recovered. Though Bucky remained asymptomatic for at least 15 years, many patients experienced relapses. By 1955, Nissen began to think back on the successful procedure in Istanbul. Now based in Basel, he operated on two patients with reflux esophagitis, wrapping a portion of the stomach around the lower esophagus. He published the results of the two cases in 1956.

By training under Sauerbruch, Nissen developed unique skill in surgery of the chest. Through his own mentoring by Polish-Austrian surgeon Jan Mikulicz-Radecki, Sauerbruch had learned to perform thoracic surgery by use of a pressure chamber before it was possible to give anesthesia to patients through breathing tubes.

In 1931, Nissen treated a 12-year-old girl who had sustained a crush injury to the chest with chronic pus production from the left lung. Nissen elected to perform left pneumonectomy, or removal of the lung. The first surgery was halted when the patient experienced asystole ("flatline"). The patient was stabilized and the second phase of the pneumonectomy was completed two weeks later. The patient survived for several years. Nissen was the first Western physician to complete the procedure; successful pneumonectomy was reported in the United States in 1933.

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