Benerito's most significant contribution was the development of cross-linking technology for cotton fabrics. This process involved chemically bonding cellulose molecules to improve wrinkle resistance, stain resistance, and other desirable properties.

Her research on cross-linking was instrumental in creating wash-and-wear cotton fabrics, which revolutionized the textile industry by reducing the need for ironing. This invention had a profound impact on consumers' lives.

Benerito obtained numerous patents for her inventions, reflecting the breadth and depth of her research in textile chemistry. These patents covered various aspects of cotton modification and treatment.

Beyond wash-and-wear cotton, Benerito also contributed to the development of flame-retardant fabrics, which enhanced the safety of clothing and other textile products. Her research also explored ways to improve the dyeability and durability of cotton.

Benerito's inventions had a lasting impact on the textile industry, improving the quality, performance, and convenience of cotton fabrics. Her work transformed the way cotton garments were manufactured and cared for.