Ryan's Hope is an American soap opera created by Claire Labine and Paul Avila Mayer, airing for 13 years on ABC from July 7, 1975, to January 13, 1989. It revolves around the trials and tribulations within a large Irish-American family in the Washington Heights neighborhood of Manhattan, New York City.

In late 1974, ABC Daytime approached Claire Labine and Paul Avila Mayer, the head writers of CBS' Love of Life, about creating a new soap opera similar to General Hospital. Labine and Mayer added a large Irish-American family — the Ryans — to what ABC was calling City Hospital. Another of the show's working titles was A Rage to Love, but that was soon changed.

Patriarch Johnny Ryan (Bernard Barrow) owned a bar, Ryan's, across from fictional Riverside Hospital in New York City. His wife, Maeve (Helen Gallagher), assisted him in his duties, as did their children: Frank, the seldom-seen Kathleen, Patrick, Mary, and Siobhan (the younger daughter being introduced in the series in 1978, having spent the first three years of the series away from New York City). The Ryans and the wealthy Coleridges were the original core families of the show. The soap took the then-unusual approach of situating itself in an actual community—the Washington Heights neighborhood of Upper Manhattan. Maeve's parish sat in the shadow of the George Washington Bridge, on 178th St. References were often made to Central Park (Delia's Crystal Palace restaurant), Sheepshead Bay in Brooklyn (mob-owned fishing boats), and other localities to provide a sense of place. "We wanted to show how New York has communities," Labine said.

Labine and Mayer also served as the executive producers of the show at this point, with George Lefferts as the producer. Lefferts was soon replaced by Robert Costello, who remained with the show until 1978. Nancy Ford co-wrote the first episode with Labine and Mayer.

The original cast consisted of Nancy Addison Altman, Bernard Barrow, Faith Catlin, Justin Deas, Michael Fairman, John Gabriel, Helen Gallagher, Michael Levin, Malcolm Groome, Rosalinda Guerra, Ron Hale, Michael Hawkins, Earl Hindman, Ilene Kristen, Frank Latimore, Kate Mulgrew, Hannibal Penney, Jr., and Diana van der Vlis.

The premise of the show for its first two years involved the blue-collar, immigrant, Catholic Ryans and the three of their five upwardly mobile adult children still residing in New York: Frank, lawyer and aspiring local politician; Pat, physician at local Riverside Hospital; and Mary, aspiring journalist. The show contrasted the cultures of tradition-minded parents with their more liberated, 1970s culture-drenched children. Older morals about lifetime marriages, church-proscribed divorce, and chastity outside of wedlock were constantly being tested by "New-World," "New-Era" urban values. Frank's political campaign for city council was challenged by a chain of events surrounding his paying off the Coleridge son who knew of the affair Frank was having with Jillian Coleridge, while Frank was married to needy, frantic Delia. The political-scandal angle was soon reiterated with Frank's short tenure in the state senate. Delia became involved with all three of Johnny Ryan's sons: Frank, Pat, and Dakota. The quasi-incestuous focus was echoed in coming years by Frank's involvement with both Coleridge sisters, Jillian and Faith, and with Faith's involvement with Ryan brothers Pat and Frank, and again with Jillian's involvement with half-brothers Frank and Dakota, and by gangster Michael Pavel's involvement with New York publisher/Frank's ex-fiancée Rae Woodward (Louise Shaffer) and her teen daughter, Kim (Kelli Maroney). Mary became irresistibly attracted to a reporter exposing Frank's blackmailing scandal, the fiery Jack Fenelli, and eventually moved in with him without benefit of marriage.

These extramarital and premarital affairs, the attendant children out of wedlock, the career-oriented women, the assertion of abortion rights: the clash of generational values in the Ryan clan was interesting to viewers (akin in some respects to the "Archie-Meathead" conflicts in the famed primetime show All in the Family), and there developed a passionate following for Kate Mulgrew's portrayal of Mary Ryan. Mary's career and personal goals were given neurotic counterpoint in Delia's machinations with Mary's brothers.

After two years of growth and success, Ryan's Hope began encountering challenges. Michael Hawkins left the role of Frank Ryan in 1976, and subsequent replacements included Andrew Robinson (1976–1978), Daniel Hugh Kelly (1978–1981), Geoffrey Pierson (1983–1985), and John Sanderford (1985–1989). In late 1977, Kate Mulgrew announced she would be leaving in January 1978. Following Mulgrew's departure, three different actresses, Mary Carney, Kathleen Tolan, and Nicolette Goulet, played Mary. It was Goulet who was in the role when story writers Labine and Mayer decided to kill off the character in December 1979. The writers initially wanted to kill off Mary when Mulgrew announced her decision to leave but ABC refused to allow the popular character to be killed off. Mary's sister, Siobhan, was brought to town to become romantically involved with a man, Joe Novak, who turned out to be a mobster, a storyline that offed Mary in a grisly bludgeoning murder when she and Jack were investigating the mafia ties of the fiancé. Malcolm Groome chose to leave the role of Dr. Pat Ryan in 1978 and was replaced with John Blazo (1978–1979), Robert Finoccoli (1979), and Patrick James Clarke (1982–1983).