Sphingosine-1-phosphate receptor 2, also known as S1PR2 or S1P₂, is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).

This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation. It has also been shown to interact with Nogo-A (RTN4), an neurite outgrowth inhibitor. S1PR2 is expressed in neuronal and vascular cells and is crucial for the migration and growth of developing and injured neuronal and vascular system.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.