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SEMA4A
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Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene.[5][6]
Function
[edit]SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.[supplied by OMIM][6]
Clinical significance
[edit]A germline variant in SEMA4A (V78M) has been demonstrated to confer risk for colorectal cancer type X.[7]
Recently it has been identified as a novel therapeutic target in Multiple myeloma.[8]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000196189 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028064 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Püschel AW, Adams RH, Betz H (May 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–948. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
- ^ a b "Entrez Gene: SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A".
- ^ Schulz E, Klampfl P, Holzapfel S, Janecke AR, Ulz P, Renner W, et al. (October 2014). "Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X". Nature Communications. 5 5191. Bibcode:2014NatCo...5.5191S. doi:10.1038/ncomms6191. PMC 4214414. PMID 25307848.
- ^ Anderson GS, Ballester-Beltran J, Giotopoulos G, Guerrero JA, Surget S, Williamson JC, et al. (April 2022). "Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma". Blood. 139 (16): 2471–2482. doi:10.1182/blood.2021015161. PMC 11022854. PMID 35134130.
Further reading
[edit]- Kikutani H, Kumanogoh A (February 2003). "Semaphorins in interactions between T cells and antigen-presenting cells". Nature Reviews. Immunology. 3 (2): 159–167. doi:10.1038/nri1003. PMID 12563299. S2CID 33203042.
- Kumanogoh A, Kikutani H (September 2003). "Immune semaphorins: a new area of semaphorin research". Journal of Cell Science. 116 (Pt 17): 3463–3470. doi:10.1242/jcs.00674. PMID 12893810.
- Elhabazi A, Marie-Cardine A, Chabbert-de Ponnat I, Bensussan A, Boumsell L (2004). "Structure and function of the immune semaphorin CD100/SEMA4D". Critical Reviews in Immunology. 23 (1–2): 65–81. doi:10.1615/CritRevImmunol.v23.i12.40. PMID 12906260.
- Kumanogoh A, Marukawa S, Suzuki K, Takegahara N, Watanabe C, Ch'ng E, et al. (October 2002). "Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2". Nature. 419 (6907): 629–633. Bibcode:2002Natur.419..629K. doi:10.1038/nature01037. PMID 12374982. S2CID 4431066.
- Abid A, Ismail M, Mehdi SQ, Khaliq S (April 2006). "Identification of novel mutations in the SEMA4A gene associated with retinal degenerative diseases". Journal of Medical Genetics. 43 (4): 378–381. doi:10.1136/jmg.2005.035055. PMC 2563224. PMID 16199541.
- Nkyimbeng-Takwi E, Chapoval SP (May 2011). "Biology and function of neuroimmune semaphorins 4A and 4D". Immunologic Research. 50 (1): 10–21. doi:10.1007/s12026-010-8201-y. PMC 3366695. PMID 21203905.
- Smith EP, Shanks K, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP (May 2011). "Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor". BMC Immunology. 12 30. doi:10.1186/1471-2172-12-30. PMC 3118960. PMID 21595947.
- Nkyimbeng-Takwi EH, Shanks K, Smith E, Iyer A, Lipsky MM, Detolla LJ, et al. (July 2012). "Neuroimmune semaphorin 4A downregulates the severity of allergic response". Mucosal Immunology. 5 (4): 409–419. doi:10.1038/mi.2012.18. PMC 3378810. PMID 22472774.
- Mogie G, Shanks K, Nkyimbeng-Takwi EH, Smith E, Davila E, Lipsky MM, et al. (November 2013). "Neuroimmune semaphorin 4A as a drug and drug target for asthma". International Immunopharmacology. 17 (3): 568–575. doi:10.1016/j.intimp.2013.08.005. PMC 3818409. PMID 23994348.
- Chapoval SP (November 2015). "Semaphorin 4A as novel regulator and promising therapeutic target in rheumatoid arthritis". Arthritis Research & Therapy. 17 313. doi:10.1186/s13075-015-0846-4 (inactive 12 July 2025). PMC 4635990. PMID 26542940.
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