SSX2IP

SSX2IP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T2M, 1XZ9, 2AIN, 2EXG
Identifiers
Aliases	SSX2IP, ADIP, synovial sarcoma, X breakpoint 2 interacting protein, SSX family member 2 interacting protein, hMsd1
External IDs	OMIM: 608690; MGI: 2139150; HomoloGene: 8522; GeneCards: SSX2IP; OMA:SSX2IP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.3 Start 84,643,706 bp[1] End 84,690,803 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H2 Start 146,110,397 bp[2] End 146,145,899 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis middle temporal gyrus sperm Brodmann area 23 jejunal mucosa Brodmann area 46 endothelial cell duodenum secondary oocyte Top expressed in Ileal epithelium seminiferous tubule spermatid olfactory epithelium lens spermatocyte fetal liver hematopoietic progenitor cell CA3 field retinal pigment epithelium entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein domain specific binding Cellular component cytoplasm microtubule organizing center adherens junction cell junction cell projection cytoskeleton cell leading edge nucleus ciliary basal body centriolar satellite protein-containing complex Biological process regulation of cell motility intraciliary transport involved in cilium assembly regulation of Rac protein signal transduction cell adhesion cell projection organization cilium assembly centrosome cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117178 99167 Ensembl ENSG00000117155 ENSMUSG00000036825 UniProt Q9Y2D8 Q8VC66 RefSeq (mRNA) NM_001166293 NM_001166294 NM_001166295 NM_001166417 NM_014021 NM_001253768 NM_001253769 NM_001253770 NM_138744 NM_001355661 RefSeq (protein) NP_001159765 NP_001159766 NP_001159767 NP_001159889 NP_054740 NP_001240697 NP_001240698 NP_001240699 NP_620083 NP_001342590 Location (UCSC) Chr 1: 84.64 – 84.69 Mb Chr 3: 146.11 – 146.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Afadin- and alpha-actinin-binding protein is a protein that in humans is encoded by the SSX2IP gene.^[5] It has been shown that it functions together with WDR8 in centrosome maturation, ensuring proper spindle length and orientation.^{[6][7][8][9][10]} The SSX2IP-WDR8 complex additionally promotes ciliary vesicle docking during ciliogenesis.^[11][12]

• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• de Bruijn DR, dos Santos NR, Kater-Baats E, Thijssen J, van den Berk L, Stap J, Balemans M, Schepens M, Merkx G, van Kessel AG (July 2002). "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP". Genes, Chromosomes & Cancer. 34 (3): 285–98. doi:10.1002/gcc.10073. PMID 12007189. S2CID 11734893.
• Asada M, Irie K, Morimoto K, Yamada A, Ikeda W, Takeuchi M, Takai Y (February 2003). "ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions". The Journal of Biological Chemistry. 278 (6): 4103–11. doi:10.1074/jbc.M209832200. PMID 12446711.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Guinn BA, Bland EA, Lodi U, Liggins AP, Tobal K, Petters S, Wells JW, Banham AH, Mufti GJ (October 2005). "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia". Biochemical and Biophysical Research Communications. 335 (4): 1293–304. doi:10.1016/j.bbrc.2005.08.024. PMID 16112646.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.

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