Sabina Mazo Isaza (born March 25, 1997) is a Colombian mixed martial artist who competed in the Flyweight (MMA) and Bantamweight (MMA) division in the Ultimate Fighting Championship (UFC). She is a two time flyweight Legacy Fighting Alliance (LFA) champion. On August 4, 2023, she became the current LFA women's strawweight champion. She started a podcast with the premier episode of Café con Mazo being released on On September 5, 2023.

Mazo was born in Medellín, Colombia, but moved with her family to Florida, United States, as a baby. After three years in United States, the family returned to Medellín where she eventually grew up. Without any preceding interest in martial arts, Mazo begun training Brazilian jiu-jitsu in Colombia at the age of fifteen. Soon after she picked up boxing and continued towards mixed martial arts.

Sabina Mazo was the two time Legacy Fighting Alliance flyweight champion and amassed a record of 6–0 prior to the signing by the UFC.

Sabina Mazo made her promotional debut against Maryna Moroz on March 30, 2019, at UFC on ESPN 2. She lost the fight via unanimous decision.

Mazo faced Shana Dobson on August 17, 2019, at UFC 241. She won the fight via unanimous decision.

Mazo next faced JJ Aldrich on January 18, 2020, at UFC 246. She won the fight by split decision.

Mazo faced Justine Kish on September 12, 2020, at UFC Fight Night 177. She won the fight via a rear-naked choke submission in round three.

Mazo faced Alexis Davis in a bantamweight bout on February 27, 2021, at UFC Fight Night 186. She lost the fight via unanimous decision.