Safe zones, de-escalation zones or no-fly zones have been proposed or created at various points during the Syrian civil war which began in 2011, including "de-escalation zones" agreed between the Turkish and Russian powers backing various belligerent parties and no-fly zones proposed in the Kurdish Northeast and rebel Northwest of the country.

Turkey and the Syrian opposition proposed a safe zone that includes some regions of northern Syria; however, the United States and the other Western states were not willing to accept these plans. After the advancements of ISIL in Iraq, Turkey and the United States negotiated a "safe zone", while the US accepted "ISIL-free zone", US officials were reluctant to accept a no fly zone.

In 2016 the Prime Minister of the United Kingdom, Theresa May, stated "The scenes we see of the indiscriminate slaughter of innocent civilians are absolutely appalling. We want to see an end to that, but there are many questions about a no-fly zone that need to be looked at: Who is it there to protect? Would it lead to [President Bashar al-]Assad bombing people in the expectation that they would then move to that zone? Who would enforce that safe area?"

Damascus rejected Turkey's proposed safe zone and also blamed the Syrian Kurds. Stating "Syria’s Kurds who have accepted to become a tool in this aggressive US-Turkish project bear a historical responsibility."

In April 2017 Îlham Ehmed, the current co-president of the Executive Council of the Autonomous Administration of North and East Syria (AANES), stated "The US must take a clear stand against Turkish aggression. We demand that the US establish a no-fly zone to protect us against further aggression" With the Kurdish People's Protection Units (YPG) also calling for a no-fly zone via Twitter stating "Only [by] declaring north Syria as a no-fly zone can YPG defend the country unhindered. Turkey must adhere to no-fly zone", among protesters which gathered in Qamishli and online.

In 2018 James Jeffrey, the United States Special Representative for Syria Engagement raised the possibility of a no-fly zone for the Syrian Kurds in Rojava, what is now the Autonomous Administration of North and East Syria (AANES), stating "Remember, we were present not in northern Iraq, but over northern Iraq in Operation Northern Watch for 13 years", also suggesting that it did not need to be US forces, but "That can be a UN force. Under [resolution] 2254, there is language on a UN-managed and operated ceasefire. That can be partner forces. That can be other countries' forces."

On October 10, 2019, Sinam Mohamad, the co-chair of the Syrian Democratic Council, the political arm of the Syrian Democratic Forces, again called for a no-fly zone in an effort to stop the attacks, she stated "We ask a for no-fly zone over our area. At least we will not have civilian casualties then"

On October 31, 2019 Îlham Ehmed argued that instead of joint patrols again called for a no-fly zone and an international force in order to monitor security on the border with Turkey.