Saint-Quentin-sur-Charente (French pronunciation: [sɛ̃ kɑ̃tɛ̃ syʁ ʃaʁɑ̃t]; Limousin: Sent Quentin) is a commune in the Charente department in Nouvelle-Aquitaine, southwestern France.

Saint-Quentin-sur-Charente, called Saint-Quentin locally, is part of the canton of Charente-Vienne. It lies on the upper course of the river Charente. The nearest larger towns are Chabanais (6 km (3.7 mi) to the northeast), Rochechouart (12 km (7.5 mi) to the east) and Confolens (20 km (12 mi) to the north). The prefecture Angoulême is 45 km (28 mi) to the southwest. It is served by several small country roads. The D161 and the D190 serve the town. The D164 passes just north of the town. The N 141 (Angoulême–Limoges) passes 4 kilometres (2.5 mi) north of the town. The nearest train station is in Chabanais, served by TER.