Santa Cruz de Lorica is a town and municipality located in the Córdoba Department, northern Colombia.

Lorica was named a Pueblo Patrimonio (heritage town) of Colombia in 2010. It is the only municipality near the Caribbean coast that was selected to be part of the Red Turística de Pueblos Patrimonio original cohort.

As per 2020 estimates, the population of Santa Cruz de Lorica was 115,461, with a density ratio of 120 persons per square kilometer.

9°13′54″N 75°49′11″W / 9.23167°N 75.8197°W / 9.23167; -75.8197