The Santalaceae, sandalwoods, are a widely distributed family of flowering plants (including small trees, shrubs, perennial herbs, and epiphytic climbers) which, like other members of Santalales, are partially parasitic on other plants. Its flowers are bisexual or, by abortion ("flower drop"), unisexual. Modern treatments of the Santalaceae include the family Viscaceae (mistletoes), previously considered distinct.

The APG II system of 2003 recognises the family and assigns it to the order Santalales in the clade core eudicots. However, the circumscription by APG is much wider than accepted by previous classifications, including the plants earlier treated in families Eremolepidaceae and Viscaceae. It includes about 1,000 species in 43 genera. Many have reported traditional and cultural uses, including as medicine.

40 genera are accepted.