Santiago Arias Naranjo (born 13 January 1992) is a Colombian professional footballer who plays as a right-back for Argentine Primera División club Independiente and the Colombia national team.

Arias began his career at La Equidad, before moving to Sporting CP in Portugal in 2011. In 2013 he signed for Dutch side PSV, where he won three Eredivisie titles and two Johan Cruyff Shield trophies, and was named Eredivisie Player of the Year for the 2017–18 season. In 2018 he transferred to Atlético Madrid in Spain, where he won the 2018 UEFA Super Cup, later having loan spells at Bayer Leverkusen and Granada. After a stint with FC Cincinnati in Major League Soccer, where he won the Supporters' Shield in 2023, he joined Bahia in 2024 before signing with Independiente in Argentina in January 2026.

At international level, Arias represented the Colombia U17 and the Colombia U20 teams before making his senior debut in 2013. He has earned over 60 caps and appeared at the 2014, 2018, and 2026 editions of the FIFA World Cup, as well as the Copa América in 2015, 2016 (where Colombia finished third), 2019, and 2024 (where Colombia finished as runners-up).

Arias was a youth product of the La Equidad academy. He was moved into the senior squad during 2009 making his professional debut that same year against Deportes Tolima. He soon became a regular for the Bogotá based club and racked up 28 appearances. His notable performances earned him the opportunity to represent his nation at the 2011 FIFA U-20 World Cup hosted in Colombia. After a successful spell at his club and internationally, he soon moved to Portugal to join the ranks of Lisbon team Sporting CP.

While representing the U20 national Colombian side in 2011, Arias attracted the scouts of Sporting CP. On 1 July 2011, Arias was ultimately signed by Sporting on a 5-year contract for a transfer free of €300,000. He made his debut in Portugal on 6 November replacing Matías Fernández in the 80th minute against U.D. Leiria. Despite making his first team debut, Arias spent most of his playing time with the B-Squad where he scored a goal in 28 appearances. He occasionally made appearances with the first squad, but never broke in for a permanent spot.

In early 2013, Arias was linked to the Dutch club PSV but nothing was finalized. In July 2013, Arias was once again linked to the club where both parties agreed on finalizing a deal. It was then reported that Arias signed a four-year contract and PSV paid Sporting €1.6 million for a package deal including fellow Sporting teammate Stijn Schaars. Upon his arrival, Arias was handed the number 13 shirt. He made his league debut on 3 August, playing a full 90 minutes in a 2–3 away win against ADO Den Haag. He made his first direct contribution for PSV as he scored the opening goal in a 3–2 home win over FC Twente. Arias made 25 league appearances for the 2013–14 Eredivisie with PSV placing fourth thus earning a place in the 2014–15 UEFA Europa League Third qualifying round.

Arias appeared for the first time in a European competition in a match against SKN St. Pölten coming on as a second-half substitute in a match where PSV won 2-3. He then appeared in four group stage matches and played the first leg of the Round of 32 against FC Zenit Saint Petersburg. Subsequent to an injury, Arias was ruled out of the second leg with his team being knocked out 4-0 on aggregate.

Despite an early exit from the Europa League, PSV were crowned 2014–15 Eredivisie thus making the conquest Arias's first European title. It was also the club's first title in eight years.