Highway 354 is a provincial highway in the Canadian province of Saskatchewan. It runs from the junction with Highway 11 (Louis Riel Trail) and Highway 642 on the east side of Bethune to the intersection of Highways 732 and 733 in the village of Dilke. In addition to providing a connection between Highway 11 and Dilke, Highway 354 also provides access to several lakeside communities along the western shore of Last Mountain Lake. It is about 20 kilometres (12 mi) long.

Highway 354 begins in the Rural Municipality of Dufferin No. 190 at the junction between Highway 11 (Louis Riel Trail) and Hwy 642 on the eastern side of the village of Bethune. It heads due north to cross the Arm River Valley (includes crossing a bridge over the river itself) to travel through rural farmland for the next several kilometres, having intersections with Moorland Road (provides access to Highwood Beach, Kedleston Beach, and Marion Heights) and Township Road 220 (provides access to Kedleston), where it enters the Rural Municipality of Sarnia No. 221. The highway now crosses a former railway line before making a sharp left turn at an intersection with Highway 733B, heading due west for about 3 kilometres (1.9 mi) to enter the eastern edge of the village of Dilke, where it comes to an end at the junction between Highway 732 and Hwy 733. The road continues east into Dilke as westbound Hwy 733. The entire of Highway 354 is a paved, two-lane highway.

From south to north: