Scott Henderson (born August 26, 1954) is an American jazz fusion and blues guitarist best known for his work with the band Tribal Tech. He was born in West Palm Beach and raised in Lake Worth Beach.

Henderson began his career as a blues-rock player. In addition to electric guitar (mostly Suhr models), Henderson plays electric sitar.

Henderson formed Tribal Tech with bass player Gary Willis in 1984. In 1991 Henderson was named No. 1 Jazz Guitarist by Guitar World magazine, and in January 1992 he was voted Best Jazz Guitarist in Guitar Player magazine's Annual Readers' Poll.

Tribal Tech reunited and released an album entitled X in 2011, but in June 2014, Henderson posted on his message board that the band would again be dissolving.

Since 1984, Henderson has taught at the Guitar Institute of Technology, which is part of the Musicians Institute in Hollywood, California.

With Tribal Tech

As Vital Tech Tones (with Steve Smith and Victor Wooten)

As HBC (with Jeff Berlin and Dennis Chambers)