Second Men's Regional League (Serbian Cyrillic: Друга мушка регионална лига, romanized: Druga muška regionalna liga) is the men's regional basketball league in Serbia. It is the 4th-tier of the basketball league system in Serbia. Founded in 2006, it is run by the Basketball Federation of Serbia (KSS).

The league, operated by the Basketball Federation of Serbia and Regional Basketball Associations, consists of six divisions, North (N), North (S), Central, East, West (Group One) and West (Group Two), which have 14 teams each. The first team in every division will be promoted to First Men's Regional League in line with the regional format.

The following are the division champions of the Second Regional League:

The following is the list of clubs for the 2021–22 season.

The North (North) division is composed of 17 clubs.

The North (South) division is composed of 11 clubs.

The Canter division is composed of 13 clubs.

The East division is composed of 10 clubs.