The secretary of state of Wyoming is the state secretary of state of the U.S. state of Wyoming. It is a constitutional office, established under the state constitution. Wyoming has no lieutenant governor, so the Secretary of State stands first in the line of succession to the governorship in case of a vacancy. The secretary of state is the keeper of the Great Seal of Wyoming and the state's official record-keeper. When the governor is traveling out-of-state, the secretary of state serves as acting governor. Karen Wheeler served as acting secretary of state following the vacancy of Ed Murray, until the appointment of Edward Buchanan in March, 2018, who himself resigned September 17, 2022.

The secretary of state's office is divided into five divisions:

Amos W. Barber became the first Wyoming secretary of state on November 8, 1890. Prior officeholders were known as Wyoming secretaries of the territory.