Semikarakorsk (Russian: Семикарако́рск) is a town and the administrative center of Semikarakorsky District in Rostov Oblast, Russia, located on the left bank of the Don River, 137 kilometers (85 mi) northeast of Rostov-on-Don, the administrative center of the oblast. Population: 23,884 (2010 census); 23,473 (2002 census); 22,704 (1989 Soviet census).

The stanitsa of Semikarakorskaya (Семикаракорская), which was founded by the Don Cossacks, was known since 1672.^{[citation needed]} The stanitsa changed its location frequently due to Don's flooding and finally was moved to its present location in 1845. It was granted urban-type settlement status in 1958 and town status in 1972.^{[citation needed]}

Within the framework of administrative divisions, Semikarakorsk serves as the administrative center of Semikarakorsky District. As an administrative division, it is incorporated within Semikarakorsky District as Semikarakorskoye Urban Settlement. As a municipal division, this administrative unit also has urban settlement status and is a part of Semikarakorsky Municipal District.