Senekal Commando was a light infantry regiment of the South African Army. It formed part of the South African Army Infantry Formation and the South African Territorial Reserve.

This unit started as a subunit of the Winburg Commando around 1900.

After the battle of Paardekraal, the Senekal Commando joined up with General de Wet. On 4 April 1900, they defeated a British column near Mostertshoek. This was followed by a siege of Brabant's Horse at Jammersberg Drift, near Wepener.

The last major engagement was the Battle of Biddulphsberg on 29 May 1900. A combined Boer force of approximately 400 men and three artillery pieces, drawn from several eastern Free State commandos under the overall command of General A.I. de Villiers, took up positions on the mountain and surrounding flats of Biddulphsberg, some 13 kilometres east of Senekal. The British force under Lieutenant-General Sir Leslie Rundle, comprising close to 4,000 men drawn from the 16th Infantry Brigade with artillery support, advanced from Senekal on 28 May and engaged the Boer positions the following morning. A veld fire driven by a wind shift swept across the advancing British troops, compounding the Boer rifle and artillery fire; British losses totalled 185 men, of whom 47 were killed or died of wounds, 130 were wounded, and eight were missing. Boer casualties were comparatively light, two men killed or fatally wounded and three wounded, though General de Villiers was struck by a bullet during the British withdrawal and subsequently died in Senekal.

By 1902, all Commando remnants were under British military control and disarmed.

By 1912, however, previous Commando members could join shooting associations.

By 1940, such commandos were controlled by the National Reserve of Volunteers.

These commandos were formally reactivated by 1948.