Sexual and gender minorities (SGM) comprise individuals whose sexual identity, sexual orientation, sexual behavior, or gender identity differ from the majority of the surrounding society. Sexual minorities include lesbians, gay men, bisexual people, and other non-heterosexual people, Gender minorities include transgender people, non-binary (including third gender), and intersex individuals. Gender, sexual and romantic minorities (GSRM) includes individuals of a minority romantic orientation such as aromanticism.

Sexual and gender minorities includes LGBTQ people as well as those who do not identify as LGBTQ. In 2015, the United States National Institutes of Health described SGM as an "umbrella term that encompasses populations included in the acronym "LGBTI" (lesbian, gay, bisexual, transgender and intersex), and those whose sexual orientation or gender identity varies. It includes those who may not self-identify as LGBTI (e.g., queer, questioning, two-spirit, asexual, men who have sex with men, women who have sex with women, gender variant), or those who have a specific medical condition affecting reproductive development (e.g., individuals with differences or disorders of sex development, who sometimes identify as intersex)."

Numerous professional and academic institutions use sexual and gender minorities or similar terminology. In 2015, the US National Institutes of Health announced the formation of the Sexual and Gender Minority Research Office.^{[needs update]}

The term sexual minority most likely was coined in the late 1960s under the influence of Lars Ullerstam's book The Erotic Minorities: A Swedish View, which is strongly in favor of tolerance and empathy to paraphilias such as pedophilia and uncommon sexualities in which people were labeled "sex criminals". The term was used as analogous to ethnic minority.

Scientist Ritch Savin-Williams supports using the term in order to accurately describe adolescent youths who may not identify as any common culturally defined sexual identity label but have attractions towards those of the same anatomical sex as themselves.

In New Zealand, New Zealand Human Rights Commission uses the Edison "rights of sexual and gender minorities" to discuss LGBT rights.

In India, the Constitutional Bench of the Supreme Court of India, when decriminalizing homosexuality in the case of Navtej Singh Johar v. Union of India (2018), said:

Individuals belonging to sexual and gender minorities experience discrimination, stigmatization, and, in some cases, denial of care on account of their sexual orientation and gender identity. However, it is important to note that 'sexual and gender minorities' do not constitute a homogenous group, and experiences of social exclusion, marginalization, and discrimination, as well as specific health needs, vary considerably. Nevertheless, these individuals are united by one factor - that their exclusion, discrimination and marginalization is rooted in societal heteronormativity and society's pervasive bias towards gender binary and opposite-gender relationships, which marginalizes and excludes all non-heteronormative sexual and gender identities.