Shakerley is a suburb of Tyldesley in the Metropolitan Borough of Wigan, Greater Manchester, England. It was anciently a hamlet in the northwest of the township of Tyldesley cum Shakerley, in the ancient parish of Leigh. The boundary between Shakerley and Hindsford is the Hindsford Brook. It remains the boundary between Tyldesley and Atherton. Hyndforth Bridge across the brook, was rebuilt in stone in 1629.

Shakerley is derived from the Old English sceacere and leah meaning the robbers woodland glade or clearing. It was recorded as Shakerlee in 1210. The ending "ley" denotes the area was once cleared of forest. Two old house names, "Higher Oak" and "Lower Oak", refer to the oak forest that once covered the area. Hindsford Brook, once the Goderic Brook, was named after a Saxon saint.

An ancient Roman road from Mamucium to Coccium (Manchester to Wigan) passed through the hamlet.

Shakerley was home to the Shakerley family who lived at Shakerley Old Hall, close to the Shakerley Brook and the old Roman road between Manchester and Wigan. It was not a manor house but a manor by reputation. Hugh Tyldesley endowed Cockersand Abbey with the hamlet of Shakerley in the early 13th century and the Shakerley family paid rent to the canons of the abbey and also paid dues to the Tyldesleys. The Shakerleys finally left the Old Hall in about 1520 and the family migrated to Cheshire. The last of the Shakerleys to live at Shakerley Old Hall, Hugh, was buried in Leigh and the hall became a farmhouse.

In 1646 the Royalist Geoffrey Shakerley was ordered to pay a fine and sequestration of his lands for his support of King Charles I. They included Shakerley Old Hall, land and the corn mill, and five nail smithies at Shakerley. In 1667 Shakerley Old Hall was a magnificent home containing the hall, cellars, brewhouse, buttery, dairy, dining room, parlour and various chambers. By 1742 it was home to a succession of tenant farmers.

The corn mill was mentioned in 1656 and Henry Hindley, miller at Shakerley died in 1697. In 1785 the mill was let to Joseph Adkin. By 1811 it had been converted into a carding and spinning shed. After that it was converted to cottages which lasted into the 20th century. The first inn to be recorded in the township was "Mather's Inn" in 1696 and the innkeeper was William Mather.

The Shakerley family, absent landlords, finally relinquished their tenure of the hamlet when it was auctioned in 1836. The sale included farms and land totalling 514 statute acres with "valuable mines of coal and stone lying under the same". The estate was bought by Jacob Fletcher of Peel Hall, Little Hulton.

Coal was got in Shakerley in the early 15th century. An armed dispute between the Shakerleys and the Tyldesleys over the digging of "seacole" was recorded in 1429. In 1748 Shakerley the most populous and industrialised part of the township of Tyldesley cum Shakerley. There was a colliery in Shakerley in 1798 owned by John Hope of Chaddock Hall. It was bought in 1836 by Jacob Fletcher when he acquired the Shakerley estate. In 1853 the owner was Nathan Fletcher. Shakerley Collieries included the Wellington and Nelson Pits. Nelson Pit was close to the Old Toll Bar. The pits became part of Manchester Collieries in 1934. Nelson Pit was closed in 1939. As the colliery was isolated from the road through Tyldesley a cobblestone road known as the Old Toll Bar Road was made across Shakerley to near Green Hall in Atherton. Shakerley Lane was a toll road until 1949 when the toll house was demolished.