The Moura massacre was carried out by Malian Armed Forces and Russian mercenaries from the Wagner Group between 27 and 31 March 2022, in the central Malian town of Moura, Mopti Region in conflict with Al-Qaeda in the Islamic Maghreb's Jama'at Nasr al-Islam wal Muslimin. Over 300 civilians are alleged to have been killed according to US-based Human Rights Watch.

Since January 2012, Mali has been embroiled in a civil war between Islamist insurgents and the Malian government. France joined the conflict the next year, but announced after the 2020 Malian coup d'état their intention to gradually reduce the number of French forces and withdraw them from the country. Mali has since looked for other ways to acquire foreign help, and has reportedly received help from a Russian private military company called the Wagner Group, which Malian and Russian forces both insisted were there to serve as military advisors only.

Human Rights Watch documented at least 71 individual cases of civilians summarily executed by security forces from December 2021 to March 2022. Islamist activities have also raised concerns, with France24 journalist Wassim Nasr suggesting the massacre was in part a retaliation for repeated attacks on the village of Dogofry, Ségou by members of the Islamist Macina Liberation Front.

The town of Moura in particular has been likened to having been under the "quasi-control" of jihadists, particularly Jama'at Nasr al-Islam wal Muslimin, which is part of Al-Qaeda in the Islamic Maghreb and has enforced sharia law on villagers. In 2022 Muhammed Kufa, AQIM's second-in-command leader, was spotted in the city.

The operation began on 27 March when government forces entered the town of Moura. Military helicopters landed near the town's market, the soldiers stepped out and approached a group of around 30 jihadists, who fired at them, killing at least two white soldiers (most likely from the Wagner Group) and an unknown number of government ones. Malian forces fired back, killing several people. Several civilians saw the scene unfold and tried to flee, but were followed by a helicopter that seemed to be deliberately firing at running civilians.

According to testimonies, Malian and white soldiers proceeded by deploying themselves across the town, blocking off exits and killing anybody who tried to escape. Security forces detained and interrogated hundreds of civilian men, often confiscating their belongings, including their telephones. Men who refused to be rounded up were shot on the spot by white mercenaries. The detainees were then sent to the river bank where they were rounded up into groups of 4, 6, or 10 and then executed en masse. Survivors told Reuters that members of the Bobo and Bellah groups were forced to dig mass graves.

Witnesses disagreed on the reasons why the men were singled out for execution, with some asserting that men wearing beards and traditional Islamic clothing were more likely to be targeted due to their similar appearances to Islamists. Others told Human Rights Watch that the people who had been executed were targeted due to their ethnic Fulani background.

The operation came to an end on 31 March. A witness told Human Rights Watch he had overheard a government officer tell someone over his walkie-talkie to "Stop killing people, let them go", and the killings stopped. At least three residents said that the military gave a speech afterwards in which they apologized for the massacre.