Simon Flexner
Simon Flexner
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Simon Flexner

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Simon Flexner

Simon Flexner (March 25, 1863 – May 2, 1946) was an American physician, scientist, administrator, and professor of experimental pathology at the University of Pennsylvania (1899–1903). He served as the first director of the Rockefeller Institute for Medical Research (1901–1935) (later developed as Rockefeller University) and a trustee of the Rockefeller Foundation. He was also a friend and adviser to John D. Rockefeller Jr.

Among Flexner's most important achievements are studies into poliomyelitis and the development of serum treatment for meningitis. Among his lab assistants were Hideyo Noguchi and Cornelius Rhoads, later directors of Memorial Hospital and the Sloan-Kettering Institute, respectively.

The bacteria species Shigella flexneri was named in recognition of Flexner. In addition, Flexner was the first to describe Flexner-Wintersteiner rosettes, a characteristic finding in retinoblastoma, a type of cancer.

Simon was born in Louisville, Kentucky, to Moritz (Morris) Flexner, a Jewish immigrant from Neumark, Bohemia, via several years in Strasbourg, France; and Ester from Roden, Germany. He was the fourth son of seven in a large family of nine children: Jacob, Henry, and Isadore; then Simon, followed by Bernard Flexner, Abraham Flexner, and Washington. The two sisters Mary and Gertrude were the youngest. Jacob became a pharmacist and physician, Bernard became a Zionist leader, and Abraham became an educator, eventually influencing the direction of medical education in the United States.

Flexner was reportedly inattentive in school, often getting into trouble and playing pranks on his peers. He narrowly survived typhoid fever but was nursed back to health by his mother, who communicated and slept in the same bed as him. In his older years, he was fired multiple times and first worked in his family's graphic studio, later becoming an indentured assistant to a local pharmacist.

Simon first gained a degree from the Louisville College of Pharmacy and worked with his brother Jacob for eight years.

He returned to college, getting his medical degree from Louisville Medical College in 1889. He did postgraduate work in pathology at Johns Hopkins University Medical School, and started teaching there. By 1899, he was a professor of pathology at the University of Pennsylvania.

Flexner was elected to the American Philosophical Society in 1901.

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