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Sodium orthovanadate
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Sodium orthovanadate
Sodium orthovanadate is the inorganic compound with the chemical formula Na3VO4. It forms a dihydrate Na3VO4·2H2O. Sodium orthovanadate is a salt of the VO3−4 oxyanion. It is a colorless, water-soluble solid.
Sodium orthovanadate is produced by dissolving vanadium(V) oxide in a solution of sodium hydroxide:
The salt features tetrahedral VO3−4 anion centers linked to octahedral Na+ cation sites.
Like many oxometalates, orthovanadate is subject to a number of reactions, which have been analyzed by 51V NMR studies. At high pH, VO3−4 ions exist in equilibrium with HVO2−4. At lower pH's, condensation ensues to give various polyoxovanadates. Ultimately, decavanadate is formed.
Vanadates exhibit a variety of biological activities, in part because they serve as structural mimics of phosphates. It acts as a competitive inhibitor of ATPases, alkaline and acid phosphatases, and protein-phosphotyrosine phosphatases, and its inhibitory effects can be reversed by dilution or the addition of ethylenediaminetetraacetic acid (EDTA).
Orthovanadate is activated by boiling and adjusting pH to ~10; this depolymerizes decavanadate into the active inhibitor, monovanadate.
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Sodium orthovanadate
Sodium orthovanadate is the inorganic compound with the chemical formula Na3VO4. It forms a dihydrate Na3VO4·2H2O. Sodium orthovanadate is a salt of the VO3−4 oxyanion. It is a colorless, water-soluble solid.
Sodium orthovanadate is produced by dissolving vanadium(V) oxide in a solution of sodium hydroxide:
The salt features tetrahedral VO3−4 anion centers linked to octahedral Na+ cation sites.
Like many oxometalates, orthovanadate is subject to a number of reactions, which have been analyzed by 51V NMR studies. At high pH, VO3−4 ions exist in equilibrium with HVO2−4. At lower pH's, condensation ensues to give various polyoxovanadates. Ultimately, decavanadate is formed.
Vanadates exhibit a variety of biological activities, in part because they serve as structural mimics of phosphates. It acts as a competitive inhibitor of ATPases, alkaline and acid phosphatases, and protein-phosphotyrosine phosphatases, and its inhibitory effects can be reversed by dilution or the addition of ethylenediaminetetraacetic acid (EDTA).
Orthovanadate is activated by boiling and adjusting pH to ~10; this depolymerizes decavanadate into the active inhibitor, monovanadate.
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