The South of Scotland Football League (SoSFL) is a senior football league based in south-west Scotland. The league sits at level 6 on the Scottish football league system, acting as a feeder to the Lowland Football League.

Founded in 1946, it is currently composed of 11 member clubs in a single division. Geographically, the league currently covers Dumfries and Galloway although clubs have previously also been located in East Ayrshire and South Lanarkshire.

Since 2014–15 it has featured in the senior pyramid system. The winners take part in an end of season promotion play-off with the East of Scotland Football League and West of Scotland Football League champions, subject to clubs meeting the required licensing criteria.

A league of the same name briefly existed during the early days of competitive football. The original South of Scotland Football League was created in 1892–93 and featured seven clubs:

The clubs preferred to play in cup competitions and traditional friendlies, so most of the league fixtures were not played. The competition was subsequently abandoned and no championship was awarded.

When league football was re-established in 1946, the Southern Counties League name could not be used because Ayr United 'A' and Kilmarnock 'A' were not members of the Southern Counties F.A.. Instead, the new competition was called the South of Scotland Football League. The first season saw the league played in two sections, East and West, but it has been played as a single league ever since.

Teams play each other on a home and away basis. In seasons where league membership has been low, clubs have played each other four times, instead of the usual twice. Recent changes in league membership have been:

Bold indicates a current league member.