SpaceX Dragon 1 is a class of fourteen partially reusable cargo spacecraft developed by SpaceX, an American private space transportation company. The spacecraft flew 23 missions between 2010 and 2020. Dragon was launched into orbit by the company's Falcon 9 launch vehicle to resupply the International Space Station (ISS). It was succeeded by the Dragon 2 spacecraft which has both crewed and cargo versions.

During its maiden flight in December 2010, Dragon became the first commercially built and operated spacecraft to be recovered successfully from orbit. On May 25, 2012, Dragon became the first commercial spacecraft to successfully rendezvous with and attach to the ISS. SpaceX contracted to deliver cargo to the ISS under NASA's Commercial Resupply Services program, and Dragon began regular cargo flights in October 2012. With the Dragon spacecraft and the Northrop Grumman’s Cygnus, NASA sought to increase its partnerships with domestic commercial aviation and aeronautics industry.

On June 3, 2017, the C106 capsule, largely assembled from previously flown components from the CRS-4 mission in September 2014, was launched again for the first time on CRS-11, after being refurbished.

The last flight of the Dragon 1 spacecraft launched March 7, 2020 (UTC) on cargo resupply mission (CRS-20) to International Space Station (ISS). This was the last mission of SpaceX's first Commercial Resupply Services (CRS-1) contract, and marked the retirement of the Dragon 1 fleet. Further SpaceX commercial resupply flights to ISS under the second Commercial Resupply Services (CRS-2) program use the Cargo Dragon variant of the Dragon 2 spacecraft, which is capable of fully automated docking with the ISS.

SpaceX began developing the Dragon spacecraft in late 2004, making a public announcement in 2006 with a plan of entering service in 2009. Also in 2006, SpaceX won a contract to use Dragon for commercial resupply services to the International Space Station for the American federal space agency, NASA.

In 2005, NASA solicited proposals for a commercial ISS resupply cargo vehicle to replace the then-soon-to-be-retired Space Shuttle, through its Commercial Orbital Transportation Services (COTS) development program. The Dragon space capsule was a part of SpaceX's proposal, submitted to NASA in March 2006. SpaceX's COTS proposal was issued as part of a team, which also included MD Robotics, the Canadian company that had built the ISS's Canadarm2.

On August 18, 2006, NASA announced that SpaceX had been chosen, along with Kistler Aerospace, to develop cargo launch services for the ISS. The initial plan called for three demonstration flights of SpaceX's Dragon spacecraft to be conducted between 2008 and 2010. SpaceX and Kistler were to receive up to US$278 million and US$207 million respectively, if they met all NASA milestones, but Kistler failed to meet its obligations, and its contract was terminated in 2007. NASA later re-awarded Kistler's contract to Orbital Sciences Corporation.

On December 23, 2008, NASA awarded a US$1.6 billion Commercial Resupply Services (CRS-1) contract to SpaceX, with contract options that could potentially increase the maximum contract value to US$3.1 billion. The contract called for 12 flights, with an overall minimum of 20,000 kilograms (44,000 lb) of cargo to be carried to the ISS.