Spanish Mexicans are citizens or residents of Mexico who identify as Spanish as a result of nationality or recent ancestry. Spanish immigration to Mexico began in the early 1500s and spans to the present day. The vast majority of Mexicans have at least partial Spanish ancestry; the northern and western regions of Mexico have a higher prevalence of Spanish heritage. There are three recognized large-scale Spanish immigration waves to the territory which is now Mexico: the first arrived during the colonial period, the second during the Porfiriato and the third after the Spanish Civil War.

The first Spanish settlement was established in February 1519 by Hernán Cortés in the Yucatan Peninsula, accompanied by about 11 ships, 500 men, 13 horses and a small number of cannons. In March 1519, Cortés formally claimed the land for the Spanish crown and by 1521 secured the Spanish conquest of the Aztec Empire.

The exploitation of mining wealth from the indigenous populations through the mechanism of colonialism allowed the Spanish to develop manufacturing and agriculture that turned the Bajío regions and the valleys of Mexico and Puebla into prosperous agricultural areas with incipient industrial activity for the colonists. However, indigenous populations were decimated by European diseases and mistreatment from the Spanish as a direct result of this.

In the 16th century, following the colonization of most of the new continents, perhaps as many as 240,000 Spaniards entered ports in the Americas. Since the conquest of the Aztec Empire, Mexico became the principal destination of Spanish colonial settlers in the 16th century. They were joined by 450,000 in the 17th century.

The first Spaniards who arrived in Mexico were soldiers and sailors from the Extremadura, Andalucía and La Mancha regions of Spain. At the end of the 16th century, both commoners and aristocrats from Spain were migrating to Mexico.

Additionally, some Canarian families colonized parts of Mexico in the 17th century (as in the case of the Azuaje families) and when the Spanish crown encouraged Canarian colonization of the Americas through the Tributo de sangre (Blood Tribute) in the 18th century, many of them settled in Yucatán, where by the 18th century they controlled the trade network that distributed goods throughout the peninsula; their descendants are still counted among the most influential families of direct Spanish descent in Mexico.

During the 20th century, another group of Canarians settled in Mexico in the early 1930s, and as with Galician and other Spanish immigrants of the time, there were high rates of illiteracy and impoverishment among them, but they adapted relatively quickly.

After the independence of Mexico and centuries of brutal colonial rule, animosity emerged against Spanish people in the new nation. From August 1827 to 1834, by a decree issued during the government of Lorenzo de Zavala, many Spaniards and their families were expelled from the State of Mexico and killed. The state government, influenced by English masons or Yorkers, based on the Plan of Iguala and Treaty of Córdoba, liberated the state by stripping Spaniards of their haciendas, farms, ranches and properties.