Spindoe is a British television series shown on ITV in the spring of 1968. It was named after the lead character, Alec Spindoe, a South London gangster; the plot of the series showed how Spindoe re-established his gangland empire after he had been supplanted during a term of imprisonment but found that once he had succeeded, he was no longer interested.

The character of London extortioner and gangland boss Alec Spindoe (played by Ray McAnally) first appeared in several episodes of Granada TV's serial The Fellows. In that series, two university academics based in Cambridge solve crimes in the outside world by pure theory, without ever leaving their university buildings. Spindoe falls foul of one of these theories when he panics over a threatening letter, in truth sent to him by one of the Fellows in the hope that he will react exactly as he does. His panic leads him to set up a jewellery shop robbery, where he is caught and arrested.

The following year, Spindoe returned in his own series, which depicted events after Spindoe's release from prison. The series, devised by Robin Chapman, tried to portray London gangland in a realistic and consequently unpleasant light. Characters can be both sympathetic and repulsive in the space of a few lines and there is little room for usual TV moralising.

At the beginning of the first episode, Spindoe is released from prison and is surprised to find that his deputy Eddie Edwards (Anthony Bate) is not there to meet him. North London gang boss Henry Mackleson (Richard Hurndall) is and offers him a chance to work for him, which Spindoe declines. Mackleson then arranges a 'demonstration' assassination attempt to impress on Spindoe his power. Spindoe discovers that his savings, crime empire and his wife Sheila, have been taken over by Edwards. By chance, he meets up with a former associate, Larry Bolsover, who is tricked into lending Spindoe his car to go and see Edwards. Edwards and his Norwegian 'chauffeur' Hans Burkwald then humiliate Spindoe, who turns the tables on Burkwald and steals his gun; he orders his wife to return to him "in two days, or die". Edwards then gives orders for Bolsover to be murdered to show that no-one should associate with Spindoe. Mackleson, hearing of the events at Edwards' house, begins his preparation to kill Sheila Spindoe and frame Alec for her murder. Burkwald, who secretly works for Mackleson rather than Edwards, arranges for his gun (complete with Spindoe's fingerprints) to be taken from him by Renata, a croupier at the club where Spindoe is gambling.

Larry Bolsover's body is discovered by the police. Spindoe goes to see a private detective Ray Scaliger (George Sewell), to get evidence of his wife's adultery and to tell him who is visiting Edwards. When he returns to Bolsover's flat, he finds the police there who tell him of Bolsover's death. After giving a statement to the police, he visits his solicitor but is again waylaid by Mackleson who repeats his offer and gets another refusal. While snooping at Edwards' house, Scaliger is spotted and captured by Burkwald, and beaten up during interrogation by Edwards. Spindoe spots the absence of his gun and realises Renata has stolen it; he is unable to persuade her to explain what happened but she does introduce him to the last man to speak to Larry Bolsover, a waiter. The waiter identifies Burkwald as the man who took Bolsover to his death. Scaliger returns to Edwards' house where he spots Edwards and Burkwald leaving (they are going to Mackleson to discuss merging their operations) and so phones Spindoe to tell him he can visit. Spindoe's letter repeating his ultimatum to his wife is delivered; Mackleson's plot to murder Sheila is put into operation. Scaliger observes the Spindoe lookalike arriving and enters the house just as Sheila is murdered using the gun with Spindoe's fingerprints (the maid is conveniently able to witness the Spindoe lookalike) Spindoe arrives to find his wife dead and Scaliger presenting him with his letter threatening to kill her.

Edwards, distressed at the death of Sheila, believes Spindoe killed her and wants revenge. Mackleson orders Renata (who has her suspicions of him) to get Spindoe out of her flat, which sets him thinking. Spindoe goes to one of his former betting shops, now part of Edwards' empire, where he meets Billy Humphries (Glynn Edwards), a former associate who has faked his death. Humphries tells Spindoe that Renata and Burkwald are all working for Mackleson, which confirms to Spindoe that Mackleson killed Sheila. Spindoe tries to get Renata to confess; she admits working for Mackleson. Scaliger, who has also worked out that Spindoe was being framed for Sheila's murder, tells the police. Spindoe then arranges a meeting with Mackleson, deliberately revealing to him that he knows Renata's role. She is summoned to Mackleson who has her face slashed with a razor as punishment. Spindoe and Humphries go to Edwards' house and when Burkwald returns he is forced to say where Edwards is. A morose Edwards is still vowing revenge against Spindoe when Spindoe arrives to confront him. Spindoe tells him Burkwald is working for Mackleson and explains why Mackleson had Sheila killed; Edwards is reluctant to believe it. Just as Spindoe is about to shoot Edwards, Scaliger intervenes and in the struggle Edwards manages to escape.

At the funeral of Sheila, Spindoe turns up despite the danger. Edwards' henchmen are about to stab him at the graveside when Spindoe spots the knife and escapes. Edwards begins to suspect Burkwald's loyalty, but is assuaged. Edwards and Burkwald are arrested for the murder of Bolsover. Spindoe is beginning to receive declarations of loyalty from his old associates but he is arrested for the murder of his wife. When they are brought face to face by the police they work out that each can clear the other. Mackleson sends his henchman Webster to try to recruit Scaliger, who refuses. Humphries also fails to persuade him to help free Spindoe but does send him to see Renata in hospital. Although Renata blames Spindoe for the attack on her, she tells Humphries how the gun was picked up in return for a pledge that Spindoe will pay for her face to be rebuilt. Humphries and Scaliger then agree to bail Spindoe out and Scaliger tells Renata's story to the police.

When Spindoe is released, he is angry that Humphries had paid Scaliger and pledged that he must help Renata (which he refuses to do). Edwards' solicitor is unable to find a legal way of bailing him so he arranges with Mackleson to spring him from the Magistrates' Court. Mackleson hides him at his house, telling Edwards that he had framed Spindoe for Sheila's murder. The police apply pressure to Burkwald who admits to working for Mackleson but refuses to sign a statement. Mackleson invites Spindoe to dinner, which Spindoe knows to be an invitation to kill and dispose of Edwards; he accepts and arranges for his reunited team to be present to carry out the murder. Edwards is duly murdered. Spindoe and Mackleson discuss the merging of their operations but Spindoe makes an excuse so that he can go back to assess his newly reconquered empire; Mackleson's deputy Webster is there to 'go through the books' with him.