Spirit River is a town in northern Alberta, Canada. It is approximately 78 km (48 mi) north of Grande Prairie and 7 km (4.3 mi) west of Rycroft at the junction of Highway 49 and Highway 731.

In the 2021 Census of Population conducted by Statistics Canada, the Town of Spirit River had a population of 992 living in 445 of its 510 total private dwellings, a change of -0.3% from its 2016 population of 995. With a land area of 3.11 km² (1.20 sq mi), it had a population density of 319.0/km² (826.1/sq mi) in 2021.

In the 2016 Census of Population conducted by Statistics Canada, the Town of Spirit River recorded a population of 995 living in 442 of its 487 total private dwellings, a -2.9% change from its 2011 population of 1,025. With a land area of 3.14 km² (1.21 sq mi), it had a population density of 316.9/km² (820.7/sq mi) in 2016.

The community is largely agricultural, being located in the fertile Peace Country. It also features an active oil and gas industry.

The name Spirit River comes from the Cree Chepe Sepe, or Ghost River.

In 1891, a trading post became the original settlement along the banks of the Spirit River. Ranching in the area started as early as the 1840s and farming in the 1880s. The first school opened in 1910. In 1915, to the northwest, on Section 22, the Edmonton, Dunvegan and British Columbia Railway subdivided a townsite called Spirit River Station. The residents and storekeepers at the old settlement then moved, creating a village in 1916. On February 16 of that year, the Herald Tribune reported that McRae & Co. opened a general store. Spirit River was incorporated as a town in 1951.

In 1923, the wheat pool was established.

In October 2013, a pipeline inspection crew working in the Saddle Hills area southwest of Spirit River unearthed a 10-metre long dinosaur fossil. It was later confirmed to be that of the duck-billed hadrosaur.