The Star Awards for Best Drama Serial is an award presented annually at the Star Awards, established in 1994.

The category was introduced in 1996 at the 3rd Star Awards ceremony, where Tofu Street received the award. It honors a Mediacorp drama serial for outstanding overall performance. Nominees are determined by a panel of judges employed by Mediacorp, and winners are selected through a majority vote by the entire judging panel.

Since its inception, the award has been presented to 26 drama serials, with 14 receiving multiple nominations. Unforgivable was the most recent winner in this category. Among all awarded dramas, The Dream Makers is the only drama serial to have won this category twice. Additionally, C.L.I.F. holds the record for the most nominations (five) without a win.