Syren was the longest lived of all the clipper ships, with a sailing life of 68 years and 7 months. She sailed in the San Francisco trade, in the Far East, and transported whaling products from Hawaii and the Arctic to New Bedford.

Syren sailed in the San Francisco trade from Boston and New York City from 1851 to 1856, making five passages. She then made a voyage from Boston and Calcutta, and served in the Boston - Honolulu - New Bedford trade until 1861. She then made four more passages in the San Francisco trade.

In 1866, Syren returned to the Boston - Honolulu - New Bedford run, a route she sailed for ten more years. In 1877, Syren began to voyage to Alaska and the Arctic to transport whale oil and the catch of whalers; she also transported coal to the north, and a load of spars from Seattle to Bath, ME.

In All About Hawaii, written in 1920, there appears the following note about Syren:

Dec. 23, 1858, ship Syren, 1064 tons, Green master, 96 days from Boston via Rio Janeiro, with cargo for this market. Feb. 23, 1860, she is back with another eastern cargo, reporting a trip of 114 days. Was the crack ship of the Brewer line of Boston packets several years. In 1868 she made the run in 105 days, and in 1872 it was 109. She also figured in the San Francisco-China trade later, and was finally condemned at Rio, July, 1888.

In 1861, Syren made a fast voyage from San Francisco to Boston of 103 days, besting the Kingfisher by 17 days. On this voyage, Syren also bested four other clippers bound for New York: Northern Light and Belle of the Seas, both by three days, and Sierra Nevada and Mary Robinson, both by 4 days.

Other ports of call during Syren's long career included: in the Far East, Manila, Whampoa and Batavia; Baker Island, Liverpool, and London. The stop at Baker Island suggests that she was engaged in the guano trade.

Another fast voyage was an 1857-round trip between Boston and Calcutta, of 99 days to Calcutta and 97 days returning.