TUBGCP5

TUBGCP5
Identifiers
Aliases	TUBGCP5, GCP5, tubulin gamma complex associated protein 5
External IDs	OMIM: 608147; MGI: 2178836; HomoloGene: 14172; GeneCards: TUBGCP5; OMA:TUBGCP5 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	23,039,572 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	55,481,425 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; Achilles tendon; ; testicle; ; corpus callosum; ; gonad; ; endometrium; ; body of pancreas; ; tonsil; ; canal of the cervix; ; smooth muscle tissue;
	Top expressed in
	spermatocyte; ; ascending aorta; ; aortic valve; ; tail of embryo; ; genital tubercle; ; neural layer of retina; ; superior cervical ganglion; ; Rostral migratory stream; ; ventricular zone; ; facial motor nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule binding; structural constituent of cytoskeleton; microtubule minus-end binding; gamma-tubulin binding;
Cellular component	centrosome; spindle pole; equatorial microtubule organizing center; microtubule organizing center; spindle pole body; microtubule; cytoskeleton; cytoplasm; cytosol; gamma-tubulin complex;
Biological process	centrosome duplication; microtubule nucleation by interphase microtubule organizing center; mitotic spindle assembly; cytoplasmic microtubule organization; microtubule cytoskeleton organization; microtubule nucleation; meiosis; mitotic cell cycle; spindle assembly;
	Sources:Amigo / QuickGO
Orthologs
	114791
	233276
	ENSG00000276856; ENSG00000275835; ENSG00000280807
	ENSMUSG00000033790
	Q96RT8
	Q8BKN5
NM_001102610; NM_052903; NM_001354372; NM_001354373; NM_001354374;
	NM_001354375; NM_001354376; NM_001354377; NM_001354378
	NM_146190; NM_001360873; NM_001360874
NP_001096080; NP_443135; NP_001341301; NP_001341302; NP_001341303;
	NP_001341304; NP_001341305; NP_001341306; NP_001341307
	NP_666302; NP_001347802; NP_001347803
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-tubulin complex component 5 is a protein that in humans is encoded by the TUBGCP5 gene.^[5]^[6] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

References

^ ^a ^b ^c ENSG00000275835, ENSG00000280807 GRCh38: Ensembl release 89: ENSG00000276856, ENSG00000275835, ENSG00000280807 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033790 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (Nov 2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex" (PDF). Mol Biol Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
^ "Entrez Gene: TUBGCP5 tubulin, gamma complex associated protein 5".

Bittel DC, Kibiryeva N, Butler MG (2006). "Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader–Willi syndrome". Pediatrics. 118 (4): e1276–83. doi:10.1542/peds.2006-0424. PMC 5453799. PMID 16982806.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Chai JH, Locke DP, Greally JM, et al. (2003). "Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons". Am. J. Hum. Genet. 73 (4): 898–925. doi:10.1086/378816. PMC 1180611. PMID 14508708.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000275835, ENSG00000280807 GRCh38: Ensembl release 89: ENSG00000276856, ENSG00000275835, ENSG00000280807 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033790 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11694571-5] Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (Nov 2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex" (PDF). Mol Biol Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.

[entrez-6] "Entrez Gene: TUBGCP5 tubulin, gamma complex associated protein 5".

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TUBGCP5

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