Tandospirone

Tandospirone, sold under the brand name Sediel, is an anxiolytic and antidepressant medication used in Japan and China, where it is marketed by Dainippon Sumitomo Pharma. It is a member of the azapirone class of drugs and is closely related to other azapirones like buspirone and gepirone.

Tandospirone was introduced for medical use in Japan in 1996 and in China in 2004.

Tandospirone is most commonly used as a treatment for anxiety and depressive disorders, such as generalised anxiety disorder and dysthymia respectively. For both indications it usually takes a couple of weeks for therapeutic effects to begin to be seen, although at higher doses more rapid anxiolytic responses have been seen. It has also been used successfully as a treatment for bruxism.

Tandospirone can be used as an effective augmentation,^{[clarification needed]} especially when coupled with fluoxetine or clomipramine.

Tandospirone might been tried successfully as an adjunctive treatment for cognitive symptoms^{[clarification needed]} in schizophrenic individuals.

Common adverse effects include:

Adverse effects with unknown frequency include:

It is not believed to be addictive but is known to produce mild withdrawal effects (e.g., anorexia) after abrupt discontinuation.