Tanjong Pagar railway station, also known as Singapore railway station or Keppel Road railway station, is a former railway station located at 30 Keppel Road in Singapore. The station was the southern terminus of the network operated by Keretapi Tanah Melayu (KTM), the main railway operator in Malaysia, until 30 June 2011 when the station ceased operations with relocation of the KTM station to Woodlands Train Checkpoint. The land on which the station and the KTM railway tracks stood was originally owned by KTM and over which Malaysia had partial sovereignty. This arrangement lasted until 30 June 2011, when rail service to Tanjong Pagar was ended and the land reverted to Singapore.

The main building of the railway station was gazetted as a national monument on 9 April 2011, completing one of the objectives of the new Points of Agreement between Malaysia and Singapore. The railway station is now integrated with Cantonment MRT station.

Before the Johor–Singapore Causeway across the Straits of Johor was built, the railway in Singapore was limited to the island. The construction of the causeway began in 1919, and it was opened to goods trains on 17 September 1923 and to passenger trains on 1 October 1923. Previously, passengers and goods, particularly to service the transportation of tin and rubber industry in Malaya were transferred at Woodlands to a ferry to Johor Bahru and the connecting train on the peninsula. Tanjong Pagar railway station was completed on 3 May 1932 and officially opened by Sir Cecil Clementi. It was around for 79 years before it ceased operations on 1 July 2011 to be reserved as the Singapore Railway Museum.

In 1859, Captain William Cloughton built the first dry dock. With the emergence of steamships and growth of shipping industry, Tanjong Pagar Dock Company was formed in 1864, building wharves in the area. The area grew and was known as the ‘New Harbour’ shortly before being renamed as Keppel Harbour in 1900 by Acting Governor, Sir Alexander Swettenham.

Subsequently, with much political demands, plans to build a railway through Singapore, primarily to service the New Harbour, came underway in 1899 and the Singapore-Kranji Railway was completed in 1903. Between 1906 & 1907, the line was extended southwards from the terminus station at Tank Road to Tanjong Pagar and the wharves. It was eventually disused due to noise complaints by nearby residents.

KTM used to run six daily KTM Intercity trains between Singapore and Kuala Lumpur, the capital city of Malaysia. It also ran several other trains between Singapore and other parts of Peninsular Malaysia, such as Kelantan state in the northeast. It also operated a shuttle service between Johor Bahru and Singapore for commuters. Until 30 June 2011, the stops in Singapore were at Woodlands (for immigration clearance by Singapore Immigration and disembarkation of passengers travelling from Malaysia) and Tanjong Pagar (embarkation and disembarkation). Since 1 July 2011, the only stop in Singapore is at Woodlands.

Tanjong Pagar and Outram Park MRT stations are approximately 1km from the Tanjong Pagar railway station.

Upon arriving in TPRS's main hall, the first thing that many encountered was Habib Railway Book Store and Money Changer. Having been part of the station scenery since 1936, it is certainly one institution that many regular passengers would patronize before embarking on their trip. Opened in 1936, the shop was where Mohd Seeni, a proprietor, used to work before taking over in 1958. He was the longest serving staff in the station.