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Tert-Amyl alcohol
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Tert-Amyl alcohol
tert-Amyl alcohol (TAA) or 2-methylbutan-2-ol (2M2B), is a branched pentanol.
Historically, TAA has been used as an anesthetic and more recently as a recreational drug. TAA is mostly a positive allosteric modulator for GABAA receptors in the same way as ethanol. The psychotropic effects of TAA and ethanol are similar, though distinct. Impact on coordination and balance are proportionately more prominent with TAA, which is significantly more potent by weight than ethanol. Its appeal as an alternative to ethanol may stem from its lack of a hangover (due to different metabolic pathways) and the fact that it is often not detected on standard drug test.
TAA is a colorless liquid with a burning flavor and an unpleasant odor similar to paraldehyde with a hint of camphor. TAA remains liquid at room temperature, making it a useful alternative solvent to tert-butyl alcohol.
TAA is primarily made by the hydration of 2-methyl-2-butene in the presence of an acidic catalyst.
Fusel alcohols like TAA are grain fermentation byproducts, and therefore trace amounts of TAA are present in many alcoholic beverages. Traces of TAA have been detected in other foods, like fried bacon, cassava and rooibos tea. TAA is also present in rabbit milk and seems to play a role in pheromone-inducing suckling in the newborn rabbit.
From about the 1880s to the 1950s, TAA was used as an anesthetic with the contemporary name of amylene hydrate, but it was rarely used because more efficient drugs existed. In the 1930s, TAA was mainly used as a solvent for the primary anesthetic tribromoethanol (TBE). Like chloroform, TBE is toxic for the liver, so the use of such solutions declined in the 1940s in humans. TBE-TAA-solutions remained in use as short-acting anesthetics for laboratory mice and rats. Such solutions are sometimes called Avertin, which was a brand name for the now discontinued TAA and TBE solution with a volume ratio of 0.5:1 made by Winthrop Laboratories. TAA has emerged recently as a recreational drug.
Ingestion or inhalation of TAA causes euphoria, sedative, hypnotic, and anticonvulsant effects similar to ethanol. When ingested, the effects of TAA may begin in about 30 minutes and can last up to 1–2 days. 2–4 grams of TAA is sufficient to produce a hypnotic effect. About 100 g of ethanol induces a similar level of sedation.
The smallest known dose of TAA that has killed a person is 30 mL.
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Tert-Amyl alcohol
tert-Amyl alcohol (TAA) or 2-methylbutan-2-ol (2M2B), is a branched pentanol.
Historically, TAA has been used as an anesthetic and more recently as a recreational drug. TAA is mostly a positive allosteric modulator for GABAA receptors in the same way as ethanol. The psychotropic effects of TAA and ethanol are similar, though distinct. Impact on coordination and balance are proportionately more prominent with TAA, which is significantly more potent by weight than ethanol. Its appeal as an alternative to ethanol may stem from its lack of a hangover (due to different metabolic pathways) and the fact that it is often not detected on standard drug test.
TAA is a colorless liquid with a burning flavor and an unpleasant odor similar to paraldehyde with a hint of camphor. TAA remains liquid at room temperature, making it a useful alternative solvent to tert-butyl alcohol.
TAA is primarily made by the hydration of 2-methyl-2-butene in the presence of an acidic catalyst.
Fusel alcohols like TAA are grain fermentation byproducts, and therefore trace amounts of TAA are present in many alcoholic beverages. Traces of TAA have been detected in other foods, like fried bacon, cassava and rooibos tea. TAA is also present in rabbit milk and seems to play a role in pheromone-inducing suckling in the newborn rabbit.
From about the 1880s to the 1950s, TAA was used as an anesthetic with the contemporary name of amylene hydrate, but it was rarely used because more efficient drugs existed. In the 1930s, TAA was mainly used as a solvent for the primary anesthetic tribromoethanol (TBE). Like chloroform, TBE is toxic for the liver, so the use of such solutions declined in the 1940s in humans. TBE-TAA-solutions remained in use as short-acting anesthetics for laboratory mice and rats. Such solutions are sometimes called Avertin, which was a brand name for the now discontinued TAA and TBE solution with a volume ratio of 0.5:1 made by Winthrop Laboratories. TAA has emerged recently as a recreational drug.
Ingestion or inhalation of TAA causes euphoria, sedative, hypnotic, and anticonvulsant effects similar to ethanol. When ingested, the effects of TAA may begin in about 30 minutes and can last up to 1–2 days. 2–4 grams of TAA is sufficient to produce a hypnotic effect. About 100 g of ethanol induces a similar level of sedation.
The smallest known dose of TAA that has killed a person is 30 mL.
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