The Cramps were an American rock band formed in 1976 and active until 2009. Their lineup rotated frequently during their existence, with the husband-and-wife duo of singer Lux Interior and guitarist Poison Ivy the only ever-present members. The band is credited as progenitors of the psychobilly subgenre, fusing elements of punk rock with rockabilly. The addition of guitarist Bryan Gregory and drummer Pam Balam resulted in the first complete lineup in April 1976. They released their debut album Songs the Lord Taught Us in 1980. The band split after the death of lead singer Interior in 2009.

Lux Interior (born Erick Lee Purkhiser) and Poison Ivy (born Kristy Marlana Wallace) met in Sacramento, California, in 1972. In light of their common artistic interests and shared devotion to record collecting, they decided to form the Cramps. Lux took his stage name from a car ad, and Ivy claimed to have received hers in a dream (she was first Poison Ivy Rorschach, taking her last name from that of the inventor of the Rorschach test). In 1973, they moved to Akron, Ohio, and then to New York in 1975, soon entering into CBGB's early punk scene with other emerging acts like Suicide, the Ramones, Patti Smith, Television, Blondie, Talking Heads, Mink DeVille, and fellow Ohio transplants Dead Boys. The lineup in 1976 was Poison Ivy Rorschach, Lux Interior, Bryan Gregory (guitar), and his sister Pam "Balam" (drums).

In a short period of time, the Cramps changed drummers twice; Miriam Linna (later of Nervus Rex, the Zantees, and the A-Bones and co-owner of Norton Records) replaced Pam Balam, and Nick Knox (formerly with the Electric Eels) replaced Linna in September 1977. In the late 1970s, the Cramps briefly shared a rehearsal space with the Fleshtones, and performed regularly in New York at clubs such as CBGB and Max's Kansas City, releasing two independent singles produced by Alex Chilton at Ardent Studios in Memphis in 1977 before being signed by Miles Copeland III to the young I.R.S. Records label. Their first tour of Great Britain was as supporting act to the Police on that band's first UK tour promoting Outlandos d'Amour.

In June 1978, they gave a landmark free concert for patients at the California State Mental Hospital in Napa, recorded on a Sony Portapak video camera by the San Francisco collective Target Video and later released as Live at Napa State Mental Hospital. Once back to the east coast, they played the revamped 1940s swing club "The Meadowbrook" in New Jersey, which had a huge stage and dance floor. Next they recorded two singles in New York City, which were later re-released on their 1979 Gravest Hits EP, before Chilton brought them back that year to Memphis to record their first full-length album, Songs the Lord Taught Us, at Phillips Recording, operated by former Sun Records label owner Sam Phillips.

The Cramps relocated to Los Angeles in 1980 and hired guitarist Kid Congo Powers of the Gun Club. While recording their second LP, Psychedelic Jungle, the band and Miles Copeland began to dispute royalties and creative rights. The ensuing court case prevented them from releasing anything until 1983, when they recorded Smell of Female live at New York's Peppermint Lounge; Kid Congo Powers subsequently departed. Mike Metoff of the Pagans (cousin of Nick Knox) was the final second guitarist – albeit only live – of the Cramps' pre-bass era. He accompanied them on an extensive European tour in 1984 (that had been canceled twice because they could not find a suitable guitarist) which included four sold out nights at the Hammersmith Palais. They also recorded performances of "Thee Most Exalted Potentate of Love" and "You Got Good Taste" which were broadcast on A Midsummer Night's Tube (1984). Smell of Female peaked at No. 74 in the UK Albums Chart.

The band appears in the 1982 film Urgh! A Music War.

In 1985 the Cramps recorded a one-off track for the horror movie The Return of the Living Dead called "Surfin' Dead", on which Ivy played bass as well as guitar. With the release of 1986's A Date With Elvis, the Cramps permanently added a bass guitar to the mix, but had trouble finding a suitable player, so Ivy temporarily filled in as the band's bassist. Jennifer "Fur" Dixon joined them on the world tour to promote the album. Their popularity in the UK was at its peak as evidenced by the six nights at Hammersmith in London, three at the Odeon (as well as many other sell out dates throughout the UK) and then three at the Palais when they returned from the continent. Each night of the tour opened with the band coming on one at a time each: Knox, Fur, Ivy and then Lux before launching into their take on Elvis Presley's "Heartbreak Hotel". The album featured what was to become a predominating theme of their work from here on: a move away from the B-movie horror focus to an increased emphasis on sexual double entendre. The album met with differing fates on either side of the Atlantic: in Europe, it sold over 250,000 copies, while in the U.S. the band had difficulty finding a record company prepared to release it until 1990. It also included their first UK Singles Chart hit: "Can Your Pussy Do the Dog?"

It was not until 1986 that the Cramps found a suitable permanent bass player: Candy del Mar (of Satan's Cheerleaders), who made her recorded debut on the raw live album RockinnReelininAucklandNewZealandxxx. This was followed by the studio album Stay Sick! in 1990, which spent one week at No. 62 in the UK Albums Chart in February of that year.