The Opera House is a music venue in Toronto, Ontario, Canada. It is one of the city's most historic performing venues, opening in 1905. It has also been a cinema and a live theatre venue. It is located at 735 Queen Street East, east of downtown in the Riverdale neighbourhood.

The building opened in 1905 as the La Plaza Theatre, an Edwardian vaudeville stage. Seating almost 700, it was the main entertainment venue in the primarily working-class neighbourhood. As films eclipsed vaudeville, the theatre was turned into a cinema, continuing to use the name La Plaza Theatre until the 1960s, and later under a series of other names.

As multiplexes made large single screen venues no longer viable as cinemas, it became a performing arts venue. In the late 1980s, it was home to the successful gospel musical Mama, I Want to Sing!. In early 1989, it was renamed "The Opera House" and became a music venue.

In 2023, the Opera House was acquired by Live Nation Canada and added to their venue portfolio.