Rhodes House is a building part of the University of Oxford in England. It is located on South Parks Road in central Oxford, and was built in memory of Cecil Rhodes, an alumnus of the university and a major benefactor. It is listed Grade II* on the National Heritage List for England.

The will of Cecil Rhodes (1853–1902) created scholarships that became known as Rhodes Scholarships, administered by the Rhodes Trust.

Construction of Rhodes House began in 1926 after the Rhodes Trust purchased the two-acre plot from Wadham College the previous year. The mansion was designed by architect Sir Herbert Baker and modelled on the Cape Dutch farmhouse design and traditional English Country mansions. This is reflected in the large beams, trans-domed windows and its Tetra-style portico. The square rubble walls were designed to be consistent with the Western European 17th century architecture of the Oxford University campus. Other features include the open-well staircase constructed from oak, featuring shaped balusters and carved eagle finials. Construction was completed in 1928 and the building and its library were handed over to Oxford University.

Rhodes House was commissioned by the Rhodes Trust as a memorial to Cecil Rhodes, to act as a centre for research for the "British Empire and Commonwealth, of African and the United States of America", and to be the headquarters of the Rhodes Scholarship system and Rhodes Trust.

Sir Herbert Baker, described as "Cecil Rhodes' own architect", was the sole-architect of Rhodes House. Architectural sculpture was provided by Charles Wheeler, who also worked on other inter-war colonial buildings including: India House, South Africa House and the Neuve Chapelle Indian Memorial. Rhodes House features a series of public rooms included a library, reading room, lecture hall and seminar rooms, a hall in which the Rhodes Scholars hold their annual dinner and the residence for the Rhodes Trust Oxford Secretary or Warden.

During 1931, Albert Einstein delivered a series of three lectures at Rhodes House. Edmund Bowen, a chemistry don at the university, saved the blackboard used in the second lecture (on 16 May). Einstein's Blackboard, now an iconic object, can still be seen at the Museum of the History of Science in Oxford, formally presented by Sir Francis Wylie, the Warden of Rhodes House at the time.

When Rhodes House was completed all the material relating to the British Empire and U.S. were transferred from the Bodleian Library. Also known as the Bodleian Library of Commonwealth & African Studies at Rhodes House. In 1990 the library held more than 330,000 books and the archives relating to US and other former colonies and dominions of the British Empire. The Library was a key research centre in the UK.

In 2014 the Library moved to the Weston Library. The Library is now known as the Commonwealth and African Studies Collections.