Whether Theresa Berkley was ever married or in a long-term relationship prior to opening her brothel is unknown. Given the era, it is plausible she had a husband or partner at some point. The nature and impact of any such relationship on her later life is purely speculative.

Her primary relationships would have been professional in nature, with her staff and potentially with suppliers or intermediaries. Personal relationships within the context of operating a brothel would have been complex and potentially risky.

There is no readily available record of Berkley having children or any known family members. This lack of documentation is not unusual for individuals involved in marginalized communities during this period.