Theresa Berkley established her brothel at Hallam Street, just east of Portland Place in Marylebone, London. The precise date of its opening is not definitively known, but it was likely in the early to mid-1820s.

Berkley's brothel became known for its specialization in flagellation and other forms of BDSM. She catered primarily to wealthy male clients seeking these services, establishing a reputation for quality and discretion.

Berkley would have managed the brothel's day-to-day operations, including overseeing staff (likely other women), managing finances, and ensuring the smooth running of the business. The size of her staff is unknown, but it would have been sufficient to cater to the demands of her clientele.

Operating a brothel, particularly one specializing in such niche and potentially scandalous activities, required a high degree of secrecy and discretion. Berkley would have taken measures to protect the identities of her clients and avoid attracting unwanted attention from the authorities.