The gens Titulena or Titulenia was an obscure plebeian family at ancient Rome. No members of this gens are mentioned in Roman writers, but several are known from inscriptions, of whom the most illustrious must have been Lucius Titulenus, a second-century governor of Raetia.

The nomen Titulenus belongs to a class of gentilicia formed from the names of places or cognomina ending in -inus. The root seems to be the cognomen Titulus, a diminutive of the praenomen Titus. Names of this type were common among gentes of Umbrian origin, and several of the Tituleni were natives of Fanum Fortunae in Umbria, or from neighboring towns from the same region.

The Tituleni known from epigraphy used several common praenomina, particularly Lucius, but also Gaius, Marcus, Quintus, and Titus. One early inscription indicates that the Tituleni also used the praenomen Vibius, which was uncommon at Rome, but more widespread in the rest of Italy.