Toonsylvania is an American animated television series, which ran for two seasons in 1998 on the Fox Kids Network block (usually placed in a block called "The No Yell Motel" that contained other scary kids' shows such as Goosebumps and Eerie, Indiana) in its first season, then was moved to Monday afternoons from September 14, 1998, until January 18, 1999, when it was cancelled. It was executive produced in part by Steven Spielberg, as DreamWorks' first animated series.

The show had recurring cartoon series that appeared in each episode. Unlike Animaniacs, Toonsylvania did not have a wide range of characters and almost every episode had the same component segments. The main segments were "Frankenstein", "Night of the Living Fred" (most episodes from season 1), "Attack of the Killer B Movies" (some episodes from season 1), "Igor's Science Minute", and "Melissa Screetch's Morbid Morals".

A typical episode of Toonsylvania starts with a cartoon series called "Frankenstein" (a parody of Mary Shelley's novel of the same name) about the adventures of Dr. Vic Frankenstein (voiced by David Warner), his assistant Igor (voiced by Wayne Knight) who always sets out to prove that he is a genius like his master, and their dim-witted Frankenstein Monster known as Phil (voiced by Brad Garrett).

During the season two restructuring, Igor, Dr. Vic Frankenstein and Phil interact with a variety of new characters, including a snooping next-door neighbor Seth Tuber (voiced by Jonathan Harris), who was based on Norman Bates from Psycho. He interacted with his "immobile" mother by putting his hand over his mouth and talking into it. There was also a typical Transylvanian angry mob that was, in fact, a cheerful group of Beatles-esque hipsters. Most of these new characters were voiced by Paul Rugg, who also improvised many of their lines.

Before the second cartoon, there is an animated vignette where Igor is on the couch with Phil and tries to use the remote control, only for a problem to occur (a running gag akin to the couch gags seen on The Simpsons) before the TV turns on to show the cartoon in question.

A segment about a family of zombies that consists of Fred Deadman (voiced by Billy West), his sister Ashley Deadman (voiced by Kath Soucie), his mother Stiffany Deadman (voiced by Valery Pappas), and his father Dedgar Deadman (voiced by Matt Frewer in season one, Jess Harnell in season two). This segment was created by cartoonist Mike Peters.

Sometimes, a parody of a B-list horror movie would air instead of a "Night of the Living Fred" cartoon. Most of them involve Ace Deuce (voiced by Tom Kenny), Professor Man (voiced by Billy West), Professor Man's daughter (voiced by Valery Pappas) whose name and occupation keeps getting changed, Ace's friend Newark (voiced by Billy West), and the general (voiced by Jim Cummings) of an army fighting different monstrous threats.

A short segment where Igor gives a science lesson (be it a song or spoken piece) that always ends in disaster.