Lysenko formed a close alliance with Isaak Izrailevich Prezent, a philosopher and lawyer who provided ideological support for Lysenko's theories and helped him navigate the political landscape.

Lysenko delivered a speech at the Second All-Union Congress of Collective Farm Stakhanovites, where he explicitly denounced genetics and championed his own Lamarckian ideas. This secured Stalin's favor.

Lysenko and his supporters actively campaigned to discredit and suppress the field of classical genetics, leading to the persecution, imprisonment, and even execution of geneticists who disagreed with his views. Nikolai Vavilov, a prominent geneticist, was among those arrested and died in prison.

Lysenko was appointed President of the All-Union Academy of Agricultural Sciences (VASKhNIL), consolidating his control over agricultural research and education in the Soviet Union.

Lysenko became Director of the Institute of Genetics of the USSR Academy of Sciences, further solidifying his dominance and allowing him to direct research according to his pseudoscientific principles.