Tskaltubo or Tsqaltubo (Georgian: წყალტუბო [ˈt͡s'χ'äɫt'ubo̞]) is a spa resort in west-central Georgia. It is the main town of the Tsqaltubo Municipality of the Imereti province. It is known for its radon-carbonate mineral springs, whose natural temperature of 33–35 °C (91–95 °F) enables the water to be used without preliminary heating.

The resort's focus is on balneotherapy for circulatory, nervous, musculo-skeletal, gynaecological and skin diseases, but since the 1970s its repertoire has included "speleotherapy", in which the cool dust-free environment of local caves is said to benefit pulmonary diseases.

Tskaltubo was especially popular in the Soviet era, attracting around 125,000 visitors a year. Bathhouse 9 features a frieze of Stalin, and visitors can see the private pool where he bathed on his visits.

Currently the spa receives only some 700 visitors a year, however, there are numerous restoration projects to promote the regeneration of this historic spa town.

Tskaltubo is located in the central part of west Georgia, in the lowland, at the foot of the Southern Caucasus, 98 meters above the sea-level, in the valley of the river Tskaltubo. It is located 9 km away from Kutaisi and 240 km from the Georgian capital Tbilisi. The climate in Tskaltubo is warm and moderately mild. The average annual temperature is +15C, and average annual precipitation is 76%. Winters here are warm and mild.

Tskaltubo is rich with karst caves. Such as “Satsurblia", "Prometheus" and "Sataplia" which provide visitors with breathtaking examples of stalactites, stalagmites, curtains, petrified waterfalls, cave pearls, underground rivers, and lakes. The temperature in the cave is always 13-15C.

Satsurblia cave is the first and only Speleotherapic - object in the Caucasus Region. The cave has unique climatic environment that gives it the ability be transformed to a recreational tourism destination for individuals with respiratory diseases ( e.g. Bronchial asthma, etc.). Speleotherapy, or underground climate-therapy, is a set of recreational therapy methods based on the use of underground microclimate to improve health.

Prometheus cave is one of the longest caves in Georgia. Visitors can see halls of Argonauts, Colchis, Medea, Love, and Prometheus and of Iberia, the excursion can be finished by foot or by a 15-minute boat ride an underground river.^{[citation needed]}