Tupi–Guarani (/tuːˈpiː ɡwɑˈrɑːni/ /ɡwɑˈɾɑ-/; Tupi-Guarani: [tuˈpi ɡwaɾaˈni]; pronunciation^ⓘ) is the most widely distributed subfamily of the Tupian languages of South America. It consists of about fifty languages, including Guarani and Old Tupi. The most widely spoken in modern times by far is Guarani, which is one of the two official languages of Paraguay.

The words petunia, jaguar, piranha, ipecac, tapioca, jacaranda, anhinga, carioca, and capoeira are of Tupi–Guarani origin.^{[citation needed]}

Rodrigues & Cabral (2012) propose eight branches of Tupí–Guaraní:

*Cabral argues that Kokama/Omagua is a mixed language, and so not directly classifiable, though most of its basic vocabulary is Tupi–Guarani.

**Not listed in Rodrigues & Cabral (2012)

Sound changes from Proto-Tupi-Guarani (PTG) defining each of the 8 Tupi-Guarani groups as listed by Rodrigues & Cabral (2002):

Michael, et al. (2015) propose the following classification for the Tupi–Guarani languages.

O'Hagan et al. (2014, 2019) proposes that Proto-Tupi-Guarani was spoken in the region of the lower Tocantins and Xingu Rivers, just to the south of Marajó Island in eastern Pará State, Brazil. Proto-Omagua-Kokama then expanded up the Amazon River, Proto-Tupinambá expanded south along the Atlantic coast, and the Southern branch expanded up along the Tocantins/Araguaia River towards the Paraná River basin.