UBE2E2

UBE2E2
Identifiers
Aliases	UBE2E2, UBCH8, ubiquitin conjugating enzyme E2 E2
External IDs	OMIM: 602163; MGI: 2384997; GeneCards: UBE2E2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y6L
Enzyme activity
Gene location (Human)
Chr.	Chromosome 3 (human)
End	23,591,794 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	3,896,121 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; prefrontal cortex; ; popliteal artery; ; tibial arteries; ; Brodmann area 9; ; germinal epithelium; ; myocardium of left ventricle; ; cingulate gyrus; ; anterior cingulate cortex; ; right coronary artery;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; motor neuron; ; Region I of hippocampus proper; ; hippocampus proper; ; fossa; ; visual cortex; ; barrel cortex; ; primary visual cortex; ; condyle; ; trigeminal ganglion;
	More reference expression data
	More reference expression data
Orthologs
Databases	NCBI: entry; OMA: entry
	7325
	218793
	ENSG00000182247
	ENSMUSG00000058317
	Q96LR5
	Q91W82
	NM_152653; NM_001370225; NM_001370226; NM_001370227; NM_001370228
	NM_144839; NM_001360327; NM_001360328
	NP_689866; NP_001357154; NP_001357155; NP_001357156; NP_001357157
	NP_659088; NP_001347256; NP_001347257
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-conjugating enzyme E2 E2 is a protein that in humans is encoded by the UBE2E2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182247 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058317 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kimura M, Hattori T, Matsuda Y, Yoshioka T, Sumi N, Umeda Y, Nakashima S, Okano Y (Dec 1997). "cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme". Cytogenet Cell Genet. 78 (2): 107–11. doi:10.1159/000134639. PMID 9371400.
^ "Entrez Gene: UBE2E2 ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)".

Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
Moynihan TP, Ardley HC, Nuber U, et al. (1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J. Biol. Chem. 274 (43): 30963–8. doi:10.1074/jbc.274.43.30963. PMID 10521492.
Niwa J, Ishigaki S, Doyu M, et al. (2001). "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity". Biochem. Biophys. Res. Commun. 281 (3): 706–13. doi:10.1006/bbrc.2001.4414. PMID 11237715.
Pringa E, Martinez-Noel G, Muller U, Harbers K (2001). "Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes". J. Biol. Chem. 276 (22): 19617–23. doi:10.1074/jbc.M100192200. PMID 11274149.
Ito K, Adachi S, Iwakami R, et al. (2001). "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725–32. doi:10.1046/j.1432-1327.2001.02169.x. PMID 11322894.
Wheeler TC, Chin LS, Li Y, et al. (2002). "Regulation of synaptophysin degradation by mammalian homologues of seven in absentia". J. Biol. Chem. 277 (12): 10273–82. doi:10.1074/jbc.M107857200. PMID 11786535.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kim KI, Giannakopoulos NV, Virgin HW, Zhang DE (2004). "Interferon-Inducible Ubiquitin E2, Ubc8, Is a Conjugating Enzyme for Protein ISGylation". Mol. Cell. Biol. 24 (21): 9592–600. doi:10.1128/MCB.24.21.9592-9600.2004. PMC 522249. PMID 15485925.
Plafker SM, Plafker KS, Weissman AM, Macara IG (2005). "Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import". J. Cell Biol. 167 (4): 649–59. doi:10.1083/jcb.200406001. PMC 2172591. PMID 15545318.
Takeuchi T, Iwahara S, Saeki Y, et al. (2005). "Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID 16428300.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Ubiquitin-conjugating enzyme E2 E2

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182247 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058317 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9371400-5] Kimura M, Hattori T, Matsuda Y, Yoshioka T, Sumi N, Umeda Y, Nakashima S, Okano Y (Dec 1997). "cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme". Cytogenet Cell Genet. 78 (2): 107–11. doi:10.1159/000134639. PMID 9371400.

[entrez-6] "Entrez Gene: UBE2E2 ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)".

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